Retelliptine

Base Information

• Chemical Name: Retelliptine
• CAS No.: 72238-02-9
• Molecular Formula: C25H32 N4 O
• Molecular Weight: 404.555
• European Community (EC) Number: 276-512-5
• UNII: SZ0F94M68J
• DSSTox Substance ID: DTXSID10222559
• Nikkaji Number: J64.265G
• Wikidata: Q27289475
• NCI Thesaurus Code: C73241
• ChEMBL ID: CHEMBL279890
• Mol file: 72238-02-9.mol

Synonyms:1-((3-(diethylamino)propyl)amino)-9-methoxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazole;BD 84;BD-84;NSC 626717D;NSC D626717;NSC-D626717;retelliptine;retelliptine dihydrochloride;retelliptine maleate;SR 95325 B;SR-95325 B

Chemical Property of Retelliptine

Chemical Property:

• Vapor Pressure: 1.26E-15mmHg at 25°C
• Boiling Point: 626.8°C at 760 mmHg
• Flash Point: 332.9°C
• PSA: 53.18000
• Density: 1.17g/cm³
• LogP: 5.71150
• XLogP3: 5.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 404.25761166
• Heavy Atom Count: 30
• Complexity: 541

Purity/Quality:

99%, ^*data from raw suppliers

RETELLIPTINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)CCCNC1=NC=CC2=C(C3=C(C(=C21)C)C4=C(N3)C=CC(=C4)OC)C

Technology Process of Retelliptine

There total 3 articles about Retelliptine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-chloro-5,11-dimethyl-9-methoxy-6H-pyrido<4,3-b>carbazole (72237-98-0) + diethylaminopropylamine (104-78-9) → Retelliptine (72238-02-9)

Guidance literature:

for 1.5h; Heating;

DOI:10.1016/S0040-4020(01)80388-4

Reference yield:

1,9-Dimethoxy-5,11-dimethyl-6H-pyrido<4,3-b>carbazole (148729-98-0) → Retelliptine (72238-02-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / POCl₃ / 4 h / Heating

2: 85 percent / 1.5 h / Heating

With trichlorophosphate;

DOI:10.1016/S0040-4020(01)80388-4

Reference yield:

→ Retelliptine (72238-02-9)

Guidance literature:

Chlorderivat 12c, γ-Diethylaminopropylamin;

upstream raw materials:

1-chloro-5,11-dimethyl-9-methoxy-6H-pyrido<4,3-b>carbazole

diethylaminopropylamine

1,9-Dimethoxy-5,11-dimethyl-6H-pyrido<4,3-b>carbazole

Refernces