Benzenecarboximidic acid,2-phenylhydrazide

Base Information

• Chemical Name: Benzenecarboximidic acid,2-phenylhydrazide
• CAS No.: 46721-85-1
• Molecular Formula: C₁₃H₁₃N₃
• Molecular Weight: 211.266
• Mol file: 46721-85-1.mol

Synonyms:

Chemical Property of Benzenecarboximidic acid,2-phenylhydrazide

Chemical Property:

• Boiling Point: 321.3±25.0 °C(Predicted)
• Density: 1.10±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenecarboximidic acid,2-phenylhydrazide

There total 17 articles about Benzenecarboximidic acid,2-phenylhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

benzonitrile (100-47-0) + phenylhydrazine (100-63-0) → N′-phenylbenzimidohydrazide (46721-85-1,110380-29-5,110380-30-8,110516-66-0,110516-68-2)

Guidance literature:

With bis(trimethylaluminum)–1,4-diazabicyclo[2.2.2]octane adduct; In toluene; at 80 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1021/acs.oprd.5b00101

Reference yield: 67.0%

N-phenylbenzohydrazonoyl chloride (15424-14-3) → N1-phenyl-benzamidrazone (46721-85-1,110380-29-5,110380-30-8,110516-66-0,110516-68-2)

Guidance literature:

With ammonia; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1016/0223-5234(87)90010-9

Reference yield: 50.0%

ethyl benzimidate hydrochloride (5333-86-8) + phenylhydrazine (100-63-0) → N1-phenyl-benzamidrazone (46721-85-1,110380-29-5,110380-30-8,110516-66-0,110516-68-2)

Guidance literature:

With pyridine; at 20 ℃;

DOI:10.1021/jacs.1c09587

upstream raw materials:

N-phenylbenzohydrazonoyl chloride

benzoyl chloride

phenylhydrazine

N-benzoyl-N'-phenylhydrazine

Downstream raw materials:

5‐methyl‐1,3‐diphenyl‐1H‐1,2,4‐triazole

2,3,5-triphenyl-Δ4-1,3,4,2-triazaboroline

5-(chloromethyl)-1,3-diphenyl-1H-1,2,4-triazole

2,5-diphenyl-2,4-dihydro-3H-1,2,4-triazol-3-one

Refernces

• 1、 Hao, Liqiang,Wang, Guodong,Sun, Jian,Xu, Jun,Li, Hongshuang,Duan, Guiyun,Xia, Chengcai,Zhang, Pengfei. "From Phenylhydrazone to 1H-1,2,4-Triazoles via Nitrification, Reduction and Cyclization". supporting information. p. 1657 - 1662. Retrieved 2020/03/19.
• 2、 Lee, Darren S.,Amara, Zacharias,Poliakoff, Martyn,Harman, Thomas,Reid, Gary,Rhodes, Barrie,Brough, Steve,McInally, Thomas,Woodward, Simon. "Investigating Scale-Up and Further Applications of DABAL-Me3 Promoted Amide Synthesis". . p. 831 - 840. Retrieved 2015/07/27.