N-(N-((Phenylmethoxy)carbonyl)-L-leucyl)glycine

Base Information

• Chemical Name: N-(N-((Phenylmethoxy)carbonyl)-L-leucyl)glycine
• CAS No.: 2706-38-9
• Molecular Formula: C16H22N2O5
• Molecular Weight: 322.361
• NSC Number: 333759
• Mol file: 2706-38-9.mol

Synonyms:EINECS 220-294-6;NSC333759;N-(N-((Phenylmethoxy)carbonyl)-L-leucyl)glycine;SCHEMBL7402633;NSC 333759;NSC-333759;FT-0772224;[(2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoyl)amino]acetic acid

Chemical Property of N-(N-((Phenylmethoxy)carbonyl)-L-leucyl)glycine

Chemical Property:

• Vapor Pressure: 2.17E-14mmHg at 25°C
• Refractive Index: 1.534
• Boiling Point: 582 °C at 760 mmHg
• Flash Point: 305.8 °C
• PSA: 104.73000
• Density: 1.203 g/cm³
• LogP: 2.31010
• Storage Temp.: 2-8°C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 322.15287181
• Heavy Atom Count: 23
• Complexity: 405

Purity/Quality:

99%+, ^*data from raw suppliers

Z-LEU-GLY-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NCC(=O)O)NC(=O)OCC1=CC=CC=C1

Technology Process of N-(N-((Phenylmethoxy)carbonyl)-L-leucyl)glycine

There total 18 articles about N-(N-((Phenylmethoxy)carbonyl)-L-leucyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-benzyloxycarbonyl-L-leucylaminoethanol (27461-77-4) → N-(N-benzyloxycarbonyl-L-leucyl)-glycine (2706-38-9)

Guidance literature:

With jones' reagent;

Reference yield:

Z-Leu-OH (2018-66-8) → N-(N-benzyloxycarbonyl-L-leucyl)-glycine (2706-38-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / DCC / CH₂Cl₂ / 10 h / Ambient temperature

2: 100 percent / Jones' reagent

With jones' reagent; dicyclohexyl-carbodiimide; In dichloromethane;

Reference yield:

Benzyloxycarbonylleucyl-glycine ethyl ester (2867-06-3) → N-(N-benzyloxycarbonyl-L-leucyl)-glycine (2706-38-9)

Guidance literature:

With 1,4-dioxane; sodium hydroxide;

upstream raw materials:

Benzyloxycarbonylleucyl-glycine ethyl ester

L-leucyl-glycine

benzyl chloroformate

N-benzyloxycarbonyl-L-thioleucine S-(4-nitro-phenyl ester)

Downstream raw materials:

N-(N-benzyloxycarbonyl-L-leucyl)-thioglycine S-(4-nitro-phenyl ester)

N-[N-(N-benzyloxycarbonyl-L-leucyl)-glycyl]-glycine ethyl ester

N-{N-[N-(N-benzyloxycarbonyl-L-leucyl)-glycyl]-glycyl}-glycine ethyl ester

L-leucyl-glycine

Refernces

• 1、 Kashima, Choji,Harada, Kazuo,Fujioka, Yoko,Maruyama, Tatsuya,Omote, Yoshimori. "Amino alcohols as C-Terminal Protecting Groups in Peptide Synthesis". . p. 535 - 540. Retrieved 2007/10/02.
• 2、 VOSS. "SYNTHESIS OF SERINE PEPTIDES. I.". . p. 116 - 121. Retrieved 2007/10/05.