5-AMINO-3-PHENYLPYRAZOLE

Base Information

• Chemical Name: 5-AMINO-3-PHENYLPYRAZOLE
• CAS No.: 827-41-8
• Molecular Formula: C9H9N3
• Molecular Weight: 159.191
• Hs Code.: 2933199090
• Mol file: 827-41-8.mol

Synonyms:TIMTEC-BB SBB005555;SALOR-INT L317837-1EA;AKOS B003768;AKOS 92617;5-PHENYL-1H-PYRAZOL-3-YLAMINE;5-PHENYL-2H-PYRAZOL-3-YLAMINE;3-PHENYL-1H-PYRAZOL-5-AMINE;BUTTPARK 30\09-86

Chemical Property of 5-AMINO-3-PHENYLPYRAZOLE

Chemical Property:

• Melting Point: 124-127 °C(lit.)
• PSA: 54.70000
• LogP: 2.24010
• Storage Temp.: -20°C Freezer

Purity/Quality:

99% ^*data from raw suppliers

3-Phenyl-1H-pyrazol-5-amine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMINO-3-PHENYLPYRAZOLE

There total 21 articles about 5-AMINO-3-PHENYLPYRAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-Nitro-2-phenyl-4H-pyrazolo[1,5-a]pyrimidin-7-one (106087-65-4) → 4-nitro-3-pyrazolone hydrazinium salt (137811-92-8) + 3-phenylpyrazol-5-amine (827-41-8)

Guidance literature:

With hydrazine hydrate; In isopropyl alcohol; for 0.5h; Heating;

DOI:10.1007/BF00474001

Reference yield: 99.0%

Benzoylacetonitrile (614-16-4) → 3-phenylpyrazol-5-amine (827-41-8)

Guidance literature:

With hydrazine hydrate; In methanol; at 150 ℃; for 0.0833333h; Temperature; Time; Solvent; Microwave irradiation;

DOI:10.3762/bjoc.14.104

Reference yield: 95.0%

3-Phenyl-2-propynonitrile (935-02-4) → 3-phenylpyrazol-5-amine (827-41-8)

Guidance literature:

With hydrazine hydrate; at 80 ℃; for 0.333333h;

DOI:10.1039/P19810002997

upstream raw materials:

acetophenone semicarbazone

diethyl ether

butyl magnesium bromide

(Z)-3-chloro-3-phenyl-2-propenenitrile

Downstream raw materials:

2-phenyl-4H-pyrazolo[1,5-a]pyrimidine-5,7-dione

N-(3-phenyl-1H-pyrazol-5-yl)acetamide

5-Methyl-2-phenylpyrazolo<5,1-a>quinazoline

5-Oxo-2,7-diphenyl-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrimidine-6-carbonitrile

Refernces

• 1、 -. "2-pyridine substituted urea structural small molecule compounds as well as synthesis and application thereof". Paragraph 0197; 0626-0628. . Retrieved 2020/03/03.
• 2、 Kelada, Mark,Walsh, John M. D.,Devine, Robert W.,McArdle, Patrick,Stephens, John C.. "Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation". supporting information. p. 122 - 1228. Retrieved 2018/06/13.