4-HYDROXY-3-PHENYLCOUMARIN

Base Information

• Chemical Name: 4-HYDROXY-3-PHENYLCOUMARIN
• CAS No.: 1786-05-6
• Molecular Formula: C15H10 O3
• Molecular Weight: 238.243
• Hs Code.: 2932209090
• Mol file: 1786-05-6.mol

Synonyms:Coumarin,4-hydroxy-3-phenyl- (6CI,7CI,8CI); 3-Phenyl-4-hydroxycoumarin;4-Hydroxy-3-phenylcoumarin; NSC 251152

Chemical Property of 4-HYDROXY-3-PHENYLCOUMARIN

Chemical Property:

• Vapor Pressure: 6.63E-07mmHg at 25°C
• Melting Point: 206-208 °C(Solv: ethanol (64-17-5))
• Boiling Point: 393.7°Cat760mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 151.5°C
• PSA: 50.44000
• Density: 1.367g/cm³
• LogP: 3.16560

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-HYDROXY-3-PHENYLCOUMARIN

There total 35 articles about 4-HYDROXY-3-PHENYLCOUMARIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-hydroxy[1]benzopyran-2-one (1076-38-6,92395-12-5) + triphenylbismuth(V) diacetate (28899-97-0,7239-60-3) → 4-hydroxy-3-phenylcoumarin (1786-05-6)

Guidance literature:

In dichloromethane; for 16h; Heating; dark;

DOI:10.1016/S0040-4020(01)89826-4

Reference yield: 90.0%

2-(phenylacetoxy)benzoic acid methyl ester (93012-49-8) → 4-hydroxy-3-phenylcoumarin (1786-05-6)

Guidance literature:

With pyridine; potassium hydroxide;

DOI:10.1080/00397910903222082

Reference yield: 86.0%

N,N-Diethyl-3-(2-hydroxy-phenyl)-3-oxo-2-phenyl-propionamide (211449-36-4) → 4-hydroxy-3-phenylcoumarin (1786-05-6)

Guidance literature:

With trifluoroacetic acid; In toluene; for 1h; Heating;

DOI:10.1016/S0040-4039(98)00977-0

upstream raw materials:

diethyl 2-phenylmalonate

phenol

4-hydroxy[1]benzopyran-2-one

phenyllead(IV) triacetate

Downstream raw materials:

4-Phenylamino-3-phenyl-<1>benzopyran-2-on

4-[(2',3')-epoxypropoxy]-3-phenyl-coumarin

4-(2-morpholin-4-yl-ethoxy)-3-phenyl-chromen-2-one

2',3'-diphenylspiro[chroman-3,1'-indene]-2,4-dione

Refernces

• 1、 Prendergast, Aisling M.,McGlacken, Gerard P.. "Regioselective Chlorination and Suzuki–Miyaura Cross-Coupling of 4-Alkoxycoumarins, 4-Alkoxy-2-pyrones, and Related Heterocycles". . p. 4827 - 4835. Retrieved 2017/09/07.
• 2、 Xi, Gao-Lei,Liu, Zai-Qun. "Coumestan inhibits radical-induced oxidation of dna: Is hydroxyl a necessary functional groupΔ". . p. 5636 - 5642. Retrieved 2015/04/22.