Pyrilamine maleate

Base Information

• Chemical Name: Pyrilamine maleate
• CAS No.: 59-33-6
• Deprecated CAS: 5572-06-5
• Molecular Formula: C17H23N3O•C4H4O4
• Molecular Weight: 401.462
• Hs Code.: 2933399090
• European Community (EC) Number: 200-422-7
• NSC Number: 757305,3604
• UNII: R35D29L3ZA
• DSSTox Substance ID: DTXSID4021216
• Wikidata: Q27287732
• NCI Thesaurus Code: C61915
• RXCUI: 82091
• ChEMBL ID: CHEMBL1201006
• Mol file: 59-33-6.mol

Synonyms:Anthisan;Boots Bite and Sting Relief;Kriptin;Maleate, Mepyramine;Maleate, Pyrilamine;Mepyramine;Mepyramine Maleate;Pyranisamine;Pyrilamine;Pyrilamine Maleate

Chemical Property of Pyrilamine maleate

Chemical Property:

• Appearance/Colour: solid
• Melting Point: 101-103 °C
• Boiling Point: 423.8 °C at 760 mmHg
• Flash Point: 210.1 °C
• PSA: 103.20000
• LogP: 2.37020
• Storage Temp.: 2-8°C
• Solubility.: Very soluble in water, freely soluble in ethanol (96 per cent).
• Water Solubility.: Soluble in water at 100mg/ml
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 9
• Exact Mass: 401.19507097
• Heavy Atom Count: 29
• Complexity: 396

Purity/Quality:

99.9% ^*data from raw suppliers

Pyrilamine maleate salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN(C)CCN(CC1=CC=C(C=C1)OC)C2=CC=CC=N2.C(=CC(=O)O)C(=O)O
• Isomeric SMILES: CN(C)CCN(CC1=CC=C(C=C1)OC)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O
• Description: Mepyramine is a first generation antihistamine that acts as an inverse agonist at the histamine H1 receptor. It is reported to bind with high affinity to a Gq/11 protein-coupled form of the receptor and to promote a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling of the endogenously expressed receptor, as well as to reduce G protein availability for other non-related receptors associated with this signaling pathway. Mepyramine has been shown to inhibit histamine-induced inositol phosphate production with a log EC50 value of -7.94.
• Uses: Mepyramine maleate is used as bulk pharmaceutical (antihistaminic). Product Data Sheet Pyrilamine maleate Selective inverse agonist for the H-1 histamine receptor. Pyrilamine Maleate is commonly utilized as a radioligand ([3H]Mepyramine) binding assay for the H1 receptor. And also used to exhibit blocking ability of KCNQ/M channels which is potentially related to an adverse effect seen in excess intake of antihistamines. A histamine H1 receptor antagonist