(E)-1-bromo-1-<4-(2-chloroethoxy)phenyl>-2-phenyl-1-butene

Base Information

• Chemical Name: (E)-1-bromo-1-<4-(2-chloroethoxy)phenyl>-2-phenyl-1-butene
• CAS No.: 129920-99-6
• Molecular Formula: C₁₈H₁₈BrClO
• Molecular Weight: 365.697
• Mol file: 129920-99-6.mol

Synonyms:(E)-1-bromo-1-<4-(2-chloroethoxy)phenyl>-2-phenyl-1-butene

Chemical Property of (E)-1-bromo-1-<4-(2-chloroethoxy)phenyl>-2-phenyl-1-butene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (E)-1-bromo-1-<4-(2-chloroethoxy)phenyl>-2-phenyl-1-butene

There total 1 articles about (E)-1-bromo-1-<4-(2-chloroethoxy)phenyl>-2-phenyl-1-butene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenyl trifluoromethanesulfonamide (456-64-4) + 1--2-phenyl-butan-1-one (103628-22-4) → (E)-1-bromo-1-<4-(2-chloroethoxy)phenyl>-2-phenyl-1-butene (129920-99-6) + (Z)-1-bromo-1-<4-(2-chloroethoxy)phenyl>-2-phenyl-1-butene (129921-00-2)

Guidance literature:

With potassium hydride; lithium bromide; Yield given. Multistep reaction. Yields of byproduct given; 1) THF, 1h, 2) THF, 4 h;

DOI:10.1021/jo00312a027

Reference yield: 99.0%

phenylzinc chloride (28557-00-8) + (E)-1-bromo-1-<4-(2-chloroethoxy)phenyl>-2-phenyl-1-butene (129920-99-6) → (Z)-1-<4-(2-chloroethoxy)phenyl>-1,2-diphenyl-1-butene (97818-83-2) + (E)-1-<4-(2-chloroethoxy)phenyl>-1,2-diphenyl-1-butene (97818-84-3)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 110 ℃; for 1h; Product distribution; other catalyst, solvent, and reaction temperature;

DOI:10.1021/jo00312a027

Reference yield: 98.0%

(E)-1-bromo-1-<4-(2-chloroethoxy)phenyl>-2-phenyl-1-butene (129920-99-6) + phenylmagnesium chloride → (Z)-1-<4-(2-chloroethoxy)phenyl>-1,2-diphenyl-1-butene (97818-83-2) + (E)-1-<4-(2-chloroethoxy)phenyl>-1,2-diphenyl-1-butene (97818-84-3)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 110 ℃; for 1h; Product distribution; other catalyst, solvent, reaction temperature and time;

DOI:10.1021/jo00312a027

upstream raw materials:

phenyl trifluoromethanesulfonamide

1--2-phenyl-butan-1-one

Downstream raw materials:

(E)-1-(4-bromophenyl)-1-<4-(2-chloroethoxy)phenyl>-2-phenyl-1-butene

(Z)-1-(4-bromophenyl)-1-<4-(2-chloroethoxy)phenyl>-2-phenyl-1-butene

(Z)-1-<4-(2-chloroethoxy)phenyl>-1,2-diphenyl-1-butene

(E)-1-<4-(2-chloroethoxy)phenyl>-1,2-diphenyl-1-butene

Refernces