C₁₃H₁₆FNO

Base Information

• Chemical Name: C₁₃H₁₆FNO
• CAS No.: 1259398-46-3
• Molecular Formula: C₁₃H₁₆FNO
• Molecular Weight: 221.275
• Mol file: 1259398-46-3.mol

Synonyms:C₁₃H₁₆FNO

Chemical Property of C₁₃H₁₆FNO

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of C₁₃H₁₆FNO

There total 1 articles about C₁₃H₁₆FNO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

morpholine (110-91-8,99108-56-2) + 1-(2-fluorophenyl)propan-1-one (446-22-0) → C13H16FNO (1259398-46-3)

Guidance literature:

With boron trifluoride diethyl etherate; Inert atmosphere;

DOI:10.1039/c4cc06863g

Reference yield: 92.0%

1-phenylprop-2-ynyl acetate (16169-88-3,84681-19-6,116119-86-9,116182-55-9) + C13H16FNO (1259398-46-3) → (2S,3R)-1-(2-fluorophenyl)-2-methyl-3-phenylpent-4-yn-1-one

Guidance literature:

With C₃₂H₂₇N₂P; copper(II) bis(trifluoromethanesulfonate); N-ethyl-N,N-diisopropylamine; In methanol; at -10 ℃; for 12h; stereoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1039/c4cc06863g

Reference yield:

C13H16FNO (1259398-46-3) + ethyl trifluoroacetaldehyde hemiacetal (433-27-2) → anti-4,4,4-trifluoro-3-hydroxy-2-methyl-1-(2-fluorophenyl)-1-butanone + syn-4,4,4-trifluoro-3-hydroxy-2-methyl-1-(2-fluorophenyl)-1-butanone

Guidance literature:

C₁₃H₁₆FNO; ethyl trifluoroacetaldehyde hemiacetal; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

With hydrogenchloride; water; In dichloromethane; at 20 ℃; for 24h; optical yield given as %de; diastereoselective reaction;

DOI:10.1021/jo101733j

upstream raw materials:

morpholine

1-(2-fluorophenyl)propan-1-one

Refernces