2-[(2-aminophenyl)ethynyl]phenylamine

Base Information

• Chemical Name: 2-[(2-aminophenyl)ethynyl]phenylamine
• CAS No.: 131298-21-0
• Molecular Formula: C₁₄H₁₂N₂
• Molecular Weight: 208.263
• Mol file: 131298-21-0.mol

Synonyms:2-[(2-aminophenyl)ethynyl]phenylamine

Chemical Property of 2-[(2-aminophenyl)ethynyl]phenylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(2-aminophenyl)ethynyl]phenylamine

There total 15 articles about 2-[(2-aminophenyl)ethynyl]phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-ethynylaniline (52670-38-9) + 2-iodophenylamine (615-43-0) → 2-[(2-aminophenyl)ethynyl]phenylamine (131298-21-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran;

DOI:10.1039/c4ob02493a

Reference yield: 93.0%

2-iodophenylamine (615-43-0) + bis-pivaloyloxyzinc acetylide → 2-[(2-aminophenyl)ethynyl]phenylamine (131298-21-0)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In dimethyl sulfoxide; at 25 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01892

Reference yield: 93.0%

1-ethynyl-2-methylbenzene (766-47-2) + 2-iodophenylamine (615-43-0) → 2-[(2-aminophenyl)ethynyl]phenylamine (131298-21-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 20 - 40 ℃; for 6h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201305579

upstream raw materials:

1,2-bis(2-nitrophenyl)ethyne

tetrachloromethane

phenylhydrazine

hydrogenchloride

Downstream raw materials:

2-(2-aminophenyl)-1H-indole

11H-indolo[3,2-c]quinoline

Refernces

• 1、 Ho, Hon Eong,Oniwa, Kazuaki,Yamamoto, Yoshinori,Jin, Tienan. "N-Methyl Transfer Induced Copper-Mediated Oxidative Diamination of Alkynes". . p. 2487 - 2490. Retrieved 2016.
• 2、 Puli, Venkat Swamy,Kilaru, Suresh,Bhongiri, Yadagiri,Marri, Sreenath Reddy,Tripathi, Anuj,Chetti, Prabhakar,Chatterjee, Anindita,Vukoti, Kiran Kumar,Pola, Someshwar. "New indolo[1,2-c]quinazolines for single-crystal field-effect transistor: A united experimental and theoretical studies". . . Retrieved 2021/08/30.