4-Dodecylmorpholine

Base Information

• Chemical Name: 4-Dodecylmorpholine
• CAS No.: 1541-81-7
• Molecular Formula: C16H33 N O
• Molecular Weight: 255.444
• European Community (EC) Number: 216-278-3
• UNII: WRS8493T84
• DSSTox Substance ID: DTXSID4042171
• Nikkaji Number: J206.768D
• Wikidata: Q27292794
• ChEMBL ID: CHEMBL439921
• Mol file: 1541-81-7.mol

Synonyms:4-dodecylmorpholine;N-dodecylmorpholine;N-dodecylmorpholine hydroiodide

Chemical Property of 4-Dodecylmorpholine

Chemical Property:

• Vapor Pressure: 0.000126mmHg at 25°C
• Melting Point: 15 °C
• Boiling Point: 334.6°Cat760mmHg
• PKA: 7.61±0.10(Predicted)
• Flash Point: 98.9°C
• Density: 0.877g/cm³
• XLogP3: 5.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 11
• Exact Mass: 255.256214676
• Heavy Atom Count: 18
• Complexity: 167

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCN1CCOCC1

Technology Process of 4-Dodecylmorpholine

There total 7 articles about 4-Dodecylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

morpholine (110-91-8,99108-56-2) + 1-dodecylbromide (143-15-7) → 4-dodecyl-morpholine (1541-81-7)

Guidance literature:

With sodium hydroxide; In water; at 130 ℃; for 6.33333h;

DOI:10.1021/acs.jafc.8b05560

Reference yield: 94.0%

morpholine (110-91-8,99108-56-2) + 1-dodecyl alcohol (112-53-8) → 4-dodecyl-morpholine (1541-81-7)

Guidance literature:

With NiCuFeO(x); In 5,5-dimethyl-1,3-cyclohexadiene; for 24h; Inert atmosphere; Sealed tube; Reflux;

DOI:10.1002/chem.201203417

Reference yield: 45.0%

n-Dodecylamine (124-22-1) + diethylene glycol (111-46-6) → 4-dodecyl-morpholine (1541-81-7)

Guidance literature:

With ruthenium trichloride; tributylphosphine; In 1,4-dioxane; at 180 ℃; for 5h;

DOI:10.1021/jo00209a004

upstream raw materials:

morpholine

1-dodecylbromide

N-lauryldiethanolamine

n-Dodecylamine

Downstream raw materials:

N-dodecylmorpholine-N-oxide

4-dodecyl-4-methyl-morpholinium; methyl sulfate

4-benzyl-4-dodecyl-morpholinium; chloride

4-ethyl-4-dodecyl-morpholinium; ethyl sulfate

Refernces

• 1、 Huang, Zhiqiang,Cheng, Chen,Li, Liqing,Guo, Zhizhong,He, Guichun,Yu, Xinyang,Liu, Rukuan,Han, Haijun,Deng, Lanqing,Fu, Weng. "Morpholine-Based Gemini Surfactant: Synthesis and Its Application for Reverse Froth Flotation of Carnallite Ore in Potassium Fertilizer Production". . p. 13126 - 13132. Retrieved 2018.
• 2、 Bhadani, Avinash,Tani, Misako,Endo, Takeshi,Sakai, Kenichi,Abe, Masahiko,Sakai, Hideki. "New ester based gemini surfactants: the effect of different cationic headgroups on micellization properties and viscosity of aqueous micellar solution". . p. 19474 - 19483. Retrieved 2015/07/27.