Technology Process of trans-cyclohexane-1,2-dicarboxylic acid mono-((3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-methoxycarbonyl-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydro-picen-3yl) ester
There total 2 articles about trans-cyclohexane-1,2-dicarboxylic acid mono-((3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-methoxycarbonyl-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydro-picen-3yl) ester which
guide to synthetic route it.
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synthetic route:
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trans-cyclohexane-1,2-dicarboxylic acid mono-((3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-methoxycarbonyl-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydro-picen-3yl) ester
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52189-19-2
trans-cyclohexane-1,2-dicarboxylic acid mono-((3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-methoxycarbonyl-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydro-picen-3yl) ester
- Guidance literature:
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trans-1,2-cyclohexanedicarboxylic anhydride; methyl glycyrrhetinate;
With
pyridine; dmap;
at 95 ℃;
for 16h;
With
hydrogenchloride; water;
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52189-19-2
trans-cyclohexane-1,2-dicarboxylic acid mono-((3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-methoxycarbonyl-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydro-picen-3yl) ester
- Guidance literature:
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Glycyrrhetinsaere-methylester: 1) trans-Cyclohexan-1,2-dicarbonsaeure, sd.Pyridin 2) HCl, Aceton;