imidazol-1-yl-oxo-acetic acid ethyl ester

Base Information

• Chemical Name: imidazol-1-yl-oxo-acetic acid ethyl ester
• CAS No.: 75716-82-4
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.152
• Hs Code.: 2933299090
• Mol file: 75716-82-4.mol

Synonyms:imidazol-1-yl-oxo-acetic acid ethyl ester

Chemical Property of imidazol-1-yl-oxo-acetic acid ethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-(1H-imidazol-1-yl)-2-oxoacetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of imidazol-1-yl-oxo-acetic acid ethyl ester

There total 1 articles about imidazol-1-yl-oxo-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1H-imidazole (288-32-4) + Ethyl oxalyl chloride (4755-77-5) → imidazol-1-yl-oxo-acetic acid ethyl ester (75716-82-4)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol101555g

Reference yield: 95.0%

1-[4-(4-fluorobenzyl)oxazole-2-yl]ethanon (500367-37-3) + imidazol-1-yl-oxo-acetic acid ethyl ester (75716-82-4) → 4-[4-(4-fluorobenzyl)oxazole-2-yl]-2-hydroxy-4-oxo-2-butenoic acid ethyl ester

Guidance literature:

1-[4-(4-fluorobenzyl)oxazole-2-yl]ethanon; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

imidazol-1-yl-oxo-acetic acid ethyl ester; In tetrahydrofuran; at -78 ℃; for 1h;

With hydrogenchloride; water; at 0 ℃;

Reference yield: 90.0%

1-(4-cyclopropylphenyl)propan-1-one (30170-62-8) + imidazol-1-yl-oxo-acetic acid ethyl ester (75716-82-4) → 4-(4-cyclopropylphenyl)-3-methyl-2,4-dioxobutyric acid ethyl ester (1034890-95-3)

Guidance literature:

1-(4-cyclopropylphenyl)propan-1-one; With lithium hexamethyldisilazane; In tert-butyl methyl ether; at -70 - -10 ℃;

imidazol-1-yl-oxo-acetic acid ethyl ester; In tert-butyl methyl ether; at -10 - 20 ℃; for 16h;

upstream raw materials:

1H-imidazole

Ethyl oxalyl chloride

Downstream raw materials:

ethyl 2-(4-chlorophenyl)-2-oxoacetate

Ethyl 2-oxobutanoate

phenylglyoxylic acid ethyl ester

ethyl (p-methoxyphenyl)oxoacetate

Refernces

• 1、 -. "SULFUR CONTAINING PYRAZOLE-HETEROCYCLE DERIVATIVES AS CANNABINOID CB1 RECEPTOR ANTAGONISTS". Page/Page column 11. . Retrieved 2011/08/04.
• 2、 -. "SULFUR CONTAINING PYRAZOLE-HETEROCYCLE DERIVATIVES AS CANNABINOID CB1 RECEPTOR ANTAGONISTS". Page/Page column 28. . Retrieved 2010/04/27.