methylene blue

Base Information

• Chemical Name: methylene blue
• CAS No.: 152071-32-4
• Molecular Formula: C₁₆H₁₈N₃S*Cl
• Molecular Weight: 319.858
• Mol file: 152071-32-4.mol

Synonyms:methylene blue

Chemical Property of methylene blue

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methylene blue

There total 32 articles about methylene blue which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3,11-dinitro-10H-phenothiazine (1747-90-6) → methylene blue (152071-32-4,105504-42-5,121067-62-7,12262-49-6,167498-52-4,6476-03-5,97130-83-1)

Guidance literature:

formaldehyd; 3,11-dinitro-10H-phenothiazine; With 5%-palladium/activated carbon; hydrogen; In water; N,N-dimethyl-formamide; at 20 - 90 ℃; for 18h; under 2850.29 - 45079.5 Torr;

With hydrogenchloride; iron(III) chloride hexahydrate; In water; N,N-dimethyl-formamide; at 5 ℃; for 2.5h; Time; Pressure; Concentration;

Reference yield: 52.0%

1-[3,7-bis(dimethylamino)phenothiazin-10-yl]ethanone (3763-06-2) → methylene blue (152071-32-4,105504-42-5,121067-62-7,12262-49-6,167498-52-4,6476-03-5,97130-83-1)

Guidance literature:

1-[3,7-bis(dimethylamino)phenothiazin-10-yl]ethanone; With hydrogenchloride; In water; at 80 ℃; for 1h;

With iron(III) chloride; In water; at 5 - 25 ℃; for 0.166667 - 0.5h; Product distribution / selectivity;

Reference yield: 51.72%

(4-(2-(thiosulfate)-4-(dimethylamino)-phenylimino)-cyclohex-2,5-dienylidene)-N,N-dimethyl ammonium (15967-15-4) → methylene blue (152071-32-4,105504-42-5,121067-62-7,12262-49-6,167498-52-4,6476-03-5,97130-83-1)

Guidance literature:

With copper(II) sulfate; at 90 ℃; for 1h;

upstream raw materials:

(4-(2-(thiosulfate)-4-(dimethylamino)-phenylimino)-cyclohex-2,5-dienylidene)-N,N-dimethyl ammonium

4-amino-N,N-dimethylaniline

p-dimethylaminonitrosobenzene

Leuco-Methylenblau

Downstream raw materials:

Leuco-Methylenblau

thionine cloride

2-azetidinone

[3,7-bis(dimethylamino)phenothiazin-10-yl]phenylmethanone

Refernces

• 1、 Jiang, Siyang,Mao, Weipeng,Mao, Dake,Li, Zhan-Ting,Ma, Da. "AND molecular logic gates based on host-guest complexation operational in live cells". . p. 881 - 884. Retrieved 2021/08/25.
• 2、 Bao, Xinlu,Yao, Yusi,Xu, Yunze,Shen, Yang,Lv, Guanglei,Zhao, Dian,Li, Chunxia. "Hypochlorous Acid Activating MB-O to Release Methylene Blue for Photodegrading of Aβ Aggregates". . p. 1992 - 1996. Retrieved 2021/09/25.