(3R)-1-(3-phenylpropyl)-3-piperidineamine

Base Information

• Chemical Name: (3R)-1-(3-phenylpropyl)-3-piperidineamine
• CAS No.: 946402-87-5
• Molecular Formula: C₁₄H₂₂N₂
• Molecular Weight: 218.342
• Mol file: 946402-87-5.mol

Synonyms:(3R)-1-(3-phenylpropyl)-3-piperidineamine

Chemical Property of (3R)-1-(3-phenylpropyl)-3-piperidineamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (3R)-1-(3-phenylpropyl)-3-piperidineamine

There total 1 articles about (3R)-1-(3-phenylpropyl)-3-piperidineamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl [(3R)-1-(3-phenylpropyl)-3-piperidinyl]carbamate (946402-84-2) → (3R)-1-(3-phenylpropyl)-3-piperidineamine (946402-87-5)

Guidance literature:

tert-butyl [(3R)-1-(3-phenylpropyl)-3-piperidinyl]carbamate; With hydrogenchloride; In ethyl acetate; at 20 ℃; for 3h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

methyl (2E)-3-(5-chloro-2-pyrazinyl)acrylate (876162-25-3) + (3R)-1-(3-phenylpropyl)-3-piperidineamine (946402-87-5) → methyl (2E)-3-[5-[((3R)-1-(3-phenylpropyl)-3-piperidinyl)amino]-2-pyrazinyl]acrylate (946402-88-6)

Guidance literature:

methyl (2E)-3-(5-chloro-2-pyrazinyl)acrylate; (3R)-1-(3-phenylpropyl)-3-piperidineamine; With potassium phosphate; In N,N-dimethyl acetamide; at 90 - 95 ℃; for 2h;

With hydrogenchloride; In N,N-dimethyl acetamide; water; pH=8.0; Product distribution / selectivity;

upstream raw materials:

tert-butyl [(3R)-1-(3-phenylpropyl)-3-piperidinyl]carbamate

Downstream raw materials:

methyl (2E)-3-[5-[((3R)-1-(3-phenylpropyl)-3-piperidinyl)amino]-2-pyrazinyl]acrylate

Refernces