1-(4-METHYLBENZYL)PIPERIDINE

Base Information

• Chemical Name: 1-(4-METHYLBENZYL)PIPERIDINE
• CAS No.: 35278-95-6
• Molecular Formula: C₁₃H₁₉N
• Molecular Weight: 189.301
• Mol file: 35278-95-6.mol

Synonyms:N,N-piperidyl-1-p-tolylmethanamine

Chemical Property of 1-(4-METHYLBENZYL)PIPERIDINE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

1-(4-METHYLBENZYL)PIPERIDINE ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-METHYLBENZYL)PIPERIDINE

There total 17 articles about 1-(4-METHYLBENZYL)PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

piperidine (110-89-4) + 4-methyl-benzaldehyde (104-87-0) → N,N-piperidyl-1-p-tolylmethanamine (35278-95-6)

Guidance literature:

With formic acid; triethylamine; In isopropyl alcohol; at 60 ℃; for 6h; Sealed tube;

DOI:10.1021/jo5000362

Reference yield: 94.0%

N-Formylpiperidine (2591-86-8) + 4-Methylbenzyl chloride (104-82-5) → N,N-piperidyl-1-p-tolylmethanamine (35278-95-6)

Guidance literature:

With NHC-Pd(II)-Im; sodium hydroxide; In water; at 50 ℃; for 3h; Inert atmosphere; Schlenk technique;

DOI:10.3184/174751913X13787959859344

Reference yield: 93.0%

4-methyl-benzaldehyde (104-87-0) + 5-aminopentanoic acid (660-88-8) → N,N-piperidyl-1-p-tolylmethanamine (35278-95-6)

Guidance literature:

With [(1,3-bis(2,4,6-trimethylphenyl) imidazol-2-ylidene)Fe(CO)₄]; phenylsilane; In toluene; at 100 ℃; for 20h; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1002/cssc.201900519

upstream raw materials:

piperidine

p-methylbenzyl thiocyanate

bis(piperidino)(4-methylphenyl)methane

4-methyl-benzaldehyde

Downstream raw materials:

N-(4-methylbenzoyl)piperidine

Refernces

• 1、 Murugan, Kaliyappan,Natarajan, Karuppannan,Nirmala, Muthukumaran,Vijayapritha, Subbarayan,Viswanathamurthi, Periasamy. "Hydrazone complexes of ruthenium(II): Synthesis, crystal structures and catalytic applications in N-alkylation reactions". . . Retrieved 2020/07/21.
• 2、 Yan, Tao,Feringa, Ben L.,Barta, Katalin. "Benzylamines via Iron-Catalyzed Direct Amination of Benzyl Alcohols". . p. 381 - 388. Retrieved 2016/01/12.