Propionic Acid

Base Information

• Chemical Name: Propionic Acid
• CAS No.: 79-09-4
• Deprecated CAS: 784139-72-6,1032826-44-0,1032826-44-0
• Molecular Formula: C₃H₆O₂
• Molecular Weight: 74.0794
• Hs Code.: 2915.50
• European Community (EC) Number: 201-176-3
• ICSC Number: 0806
• UN Number: 1848
• UNII: JHU490RVYR
• DSSTox Substance ID: DTXSID8025961,DTXSID001015846
• Nikkaji Number: J1.963A
• Wikipedia: Propionic acid
• Wikidata: Q422956
• NCI Thesaurus Code: C61911
• RXCUI: 34658
• Metabolomics Workbench ID: 25
• ChEMBL ID: CHEMBL14021
• Mol file: 79-09-4.mol

Synonyms:chromium propionate;ethylformic acid;lithium propanoate;Monoprop;potassium propionate;propionic acid;propionic acid, zinc salt;zinc propionate

Chemical Property of Propionic Acid

Chemical Property:

• Appearance/Colour: Clear, colorless liquid
• Vapor Pressure: 2.4 mm Hg ( 20 °C)
• Melting Point: -22 °C(lit.)
• Refractive Index: 1.385-1.387
• Boiling Point: 141.693 °C at 760 mmHg
• PKA: 4.86(at 25℃)
• Flash Point: 57.705 °C
• PSA: 37.30000
• Density: 1.019 g/cm³
• LogP: 0.48100
• Storage Temp.: 0-6°C
• Solubility.: organic solvents: soluble(lit.)
• Water Solubility.: 37 g/100 mL
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 74.036779430
• Heavy Atom Count: 5
• Complexity: 40.2
• Transport DOT Label: Corrosive

Purity/Quality:

99% ^*data from raw suppliers

Propionic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 36/37/38-34-10
• Safety Statements: 26-36-45-23

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Organic Acids
• Canonical SMILES: CCC(=O)O
• Recent ClinicalTrials: Investigating Optimal Propionate Delivery to the Colon Using Stable Isotope Labeling
• Inhalation Risk: A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.
• Effects of Short Term Exposure: The substance is corrosive to the eyes, skin and respiratory tract.
• Description: First described by Johann Gottlieb in 1844, propanoic acid has become one of the most widely used additives in processed foods for human consumption and animal feedstocks. Originally, Gottlieb found the compound among the degradation products of certain sugars. The term – propionic acid – itself has the unique distinction of once being the designation for all fatty acids due to the writings of Jean-Baptiste Dumas, who, in 1847, postulated that all fatty acids were in reality just one compound. While larger chain fatty acids are important components of all living things, propionic acid is the shortest fatty acid that exhibits the classic behaviors of similar compounds.
• Uses: Propionic acid is used in the productionof propionates used as mold inhibitors andpreservatives for grains and wood chips, inthe manufacture of fruit flavors and perfumebases, and as an esterifying agent. Propionic Acid is the acid source of the propionates. propionic acid in the liquid form has a strong odor and is corrosive, so it is used as the sodium, calcium, and potassium salts as a preservative. these yield the free acid in the ph range of the food in which they are used. it functions principally against mold. see calcium propionate; sodium propionate.
• Clinical Use: Propionic acid is an antifungal agent that is nonirritatingand nontoxic. After application, it is present in perspiration in low concentration ( 0.01%). Salt forms with sodium,potassium, calcium, and ammonium are also fungicidal.Propionic acid is a clear, corrosive liquid with a characteristicodor. It is soluble in water and alcohol. Thesalts are usually used because they are nonvolatile andodorless.

Technology Process of Propionic Acid

There total 1065 articles about Propionic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.5%

LACTIC ACID (849585-22-4,106989-11-1,26811-96-1,31587-11-8,26100-51-6) + acetic acid (64-19-7,77671-22-8) → 2-acetoxypropionic acid (535-17-1) + propionic acid (802294-64-0,79-09-4)

Guidance literature:

With sulfuric acid; hydrogen; sodium iodide; In water; at 180 ℃; for 1h; under 20686.5 Torr; Temperature; Green chemistry;

DOI:10.1039/d0gc02676j

Reference yield: 0.04%

maleic acid (110-16-7,26099-09-2) → tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + 4-butanolide (96-48-0) + Butane-1,4-diol (110-63-4) + 4-hydroxybutanoic acid (591-81-1) + malic acid (617-48-1,78644-42-5) + succinic acid (110-15-6) + terephthalic acid (100-21-0) + acetic acid (64-19-7,77671-22-8) + propionic acid (802294-64-0,79-09-4) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2)

Guidance literature:

With hydrogen; 0.5percent Pd/0.2percent Re on Rutile TiO₂; at 110 ℃; for 170 - 1009h; Product distribution / selectivity;

Reference yield:

p-cresol (106-44-5) → 4-methyl-2-nitrophenol (119-33-5) + 2,6-dinitro-p-cresol (609-93-8) + acetic acid (64-19-7,77671-22-8) + propionic acid (802294-64-0,79-09-4)

Guidance literature:

beim Nitrieren;

upstream raw materials:

propan-1-ol

tetrachloromethane

peracetic acid

hex-3-yne

Downstream raw materials:

2,5-diphenyl-2-propionyloxy-furan-3-one

3-(4-bromo-phenyl)-4-methyl-furazan 2-oxide

2-isopropyl-1,4-diphenyl-but-2c-ene-1,4-dione

3-benzoyl-1-phenyl-2-pentene-1,4-dione

Refernces

• 1、 Suga, Tatsuya,Shida, Naoki,Atobe, Mahito. "Au-catalyzed electrochemical oxidation of alcohols using an electrochemical column flow cell". . . Retrieved 2021.
• 2、 Rodgers, Kenton R.,Arafa, Isam M.,Goff, Harold M.. "Iron Porphyrin catalysed Oxidation of Propanal and Cyclohexene by Molecular Oxygen". . p. 1323 - 1324. Retrieved 1990.
• 3、 Bisht, Shveta,Rajaram, Venkatesan,Bharath, Sakshibeedu R.,Kalyani, Josyula Nitya,Khan, Farida,Rao, Appaji N.,Savithri, Handanahal S.,Murthy, Mathur R. N.. "Crystal structure of Escherichia coli diaminopropionate ammonia-lyase reveals mechanism of enzyme activation and catalysis". . p. 20369 - 20381. Retrieved 2012.
• 4、 Wang, Yanping,Huang, Xin,Liao, Xuepin,Shi, Bi. "Preparation of highly active and reusable heterogeneous Al 2O3-Pd catalysts by the sol-gel method using bayberry tannin as stabilizer". . p. 1609 - 1618. Retrieved 2012.
• 5、 Yang, Cuixian,Feng, Hanzhou,Stone, Kevin. "Characterization of Propionyl Phosphate Hydrolysis Kinetics by Data-Rich Experiments and In-Line Process Analytical Technology". . p. 507 - 515. Retrieved 2021.
• 6、 WOOD,KULKA,EDSON. "The metabolism of [1-14C] glucose in an enzyme system from Propionibacterium.". . p. 177 - 182. Retrieved 1956.
• 7、 Aniya, Vineet,Jain, Suman L.,Khan, Shafiur Rehman,Khatri, Praveen K.,Kumari, Alka,Naresh, K.,Ray, Anjan,Saini, Sandhya. "CO2 as oxidant: an unusual light-assisted catalyst free oxidation of aldehydes to acids under mild conditions". . p. 2208 - 2211. Retrieved 2022/02/17.
• 8、 Fu, Qiang,Liang, Fu-Shun,Lou, Da-Wei,Pan, Gao-Feng,Wang, Rui,Wu, Min,Xie, Kai-Jun. "Transformation of Thioacids into Carboxylic Acids via a Visible-Light-Promoted Atomic Substitution Process". supporting information. p. 2020 - 2024. Retrieved 2022/03/31.