(5-hydroxy-1-methylpyrazol-4-yl)-(3-chloro-2-methyl-4-(methylsulfonyl)phenyl)ketone

Base Information

• Chemical Name: (5-hydroxy-1-methylpyrazol-4-yl)-(3-chloro-2-methyl-4-(methylsulfonyl)phenyl)ketone
• CAS No.: 1035198-83-4
• Molecular Formula: C₁₃H₁₃ClN₂O₄S
• Molecular Weight: 328.776
• Mol file: 1035198-83-4.mol

Synonyms:(5-hydroxy-1-methylpyrazol-4-yl)-(3-chloro-2-methyl-4-(methylsulfonyl)phenyl)ketone

Chemical Property of (5-hydroxy-1-methylpyrazol-4-yl)-(3-chloro-2-methyl-4-(methylsulfonyl)phenyl)ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5-hydroxy-1-methylpyrazol-4-yl)-(3-chloro-2-methyl-4-(methylsulfonyl)phenyl)ketone

There total 2 articles about (5-hydroxy-1-methylpyrazol-4-yl)-(3-chloro-2-methyl-4-(methylsulfonyl)phenyl)ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon monoxide (201230-82-2) + 1-methyl-5-hydroxypyrazole (33641-15-5) + 2,6-dichloro-3-(methylsulfonyl)toluene (496805-63-1) → (5-hydroxy-1-methylpyrazol-4-yl)-(3-chloro-2-methyl-4-(methylsulfonyl)phenyl)ketone (1035198-83-4)

Guidance literature:

1-methyl-5-hydroxypyrazole; 2,6-dichloro-3-(methylsulfonyl)toluene; With potassium carbonate; triethylamine; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In 1,4-dioxane; Autoclave;

carbon monoxide; In 1,4-dioxane; at 130 ℃; for 12h; under 15001.5 Torr; Product distribution / selectivity;

Reference yield:

1-methyl-5-hydroxypyrazole (33641-15-5) + 3-chloro-2-methyl-4-(methylsulfonyl)benzoic acid (216486-04-3) → (5-hydroxy-1-methylpyrazol-4-yl)-(3-chloro-2-methyl-4-(methylsulfonyl)phenyl)ketone (1035198-83-4)

Guidance literature:

3-chloro-2-methyl-4-(methylsulfonyl)benzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In chloroform; at 20 - 40 ℃; for 4.5h;

1-methyl-5-hydroxypyrazole; With triethylamine; In chloroform; at 20 ℃; for 5h; Reflux;

1-methyl-5-hydroxypyrazole; With triethylamine; 2-hydroxy-2-methylpropanenitrile; In acetonitrile; at 40 ℃; for 12h; Product distribution / selectivity;

upstream raw materials:

carbon monoxide

1-methyl-5-hydroxypyrazole

2,6-dichloro-3-(methylsulfonyl)toluene

3-chloro-2-methyl-4-(methylsulfonyl)benzoic acid

Refernces