diphenyl propylamino phosphate

Base Information

• Chemical Name: diphenyl propylamino phosphate
• CAS No.: 5756-03-6
• Molecular Formula: C₁₅H₁₈NO₃P
• Molecular Weight: 291.287
• Mol file: 5756-03-6.mol

Synonyms:diphenyl propylamino phosphate

Chemical Property of diphenyl propylamino phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diphenyl propylamino phosphate

There total 6 articles about diphenyl propylamino phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

propylamine (107-10-8,42939-71-9) + diphenyl phosphoryl azide (26386-88-9) → diphenyl propylamino phosphate (5756-03-6)

Guidance literature:

With tris(pentafluorophenyl)borate; sodium hydrogencarbonate; 1,2-dichloro-ethane; In neat (no solvent); at 20 ℃; for 0.333333h; Reagent/catalyst; Time; Catalytic behavior; Green chemistry;

DOI:10.1039/d1cy01314a

Reference yield: 85.0%

propylamine (107-10-8,42939-71-9) + chlorophosphoric acid diphenyl ester (2524-64-3) → diphenyl propylamino phosphate (5756-03-6)

Guidance literature:

With trimethylamine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1039/c7cc04950a

Reference yield:

chlorophosphoric acid diphenyl ester (2524-64-3) → diphenyl propylamino phosphate (5756-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium azide / acetonitrile / 12 h / 0 - 25 °C / Inert atmosphere

2: sodium carbonate; zinc(II) acetylacetonate / 1,4-dioxane / 3.5 h / 40 °C / Inert atmosphere

With sodium azide; sodium carbonate; zinc(II) acetylacetonate; In 1,4-dioxane; acetonitrile;

DOI:10.1002/asia.202000154

upstream raw materials:

propyl-amidophosphoryl chloride

phenol

propylamine

diphenyl hydrogen phosphite

Downstream raw materials:

propylamine

diphenyl hydrogen phosphate

Refernces

• 1、 Jia, Nan,Jiao, Lin-Yu,Li, Zhuo,Peng, Xin-Hua,Wang, Ze-Lin. "When phosphoryl azide meets mechanochemistry: Clean, rapid, and efficient synthesis of phosphoryl amides under B(C6F5)3catalysis in a ball mill". . p. 6659 - 6665. Retrieved 2021/10/25.
• 2、 Li, Qing,Sun, Xiaohua,Yang, Xiaoqin,Wu, Minghu,Sun, Shaofa,Chen, Xiuling. "Transition-metal-free amination phosphoryl azide for the synthesis of phosphoramidates". . p. 16040 - 16043. Retrieved 2019/06/10.