2-[2-(2-{2-[2-(2-Benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethylamine

Base Information

• Chemical Name: 2-[2-(2-{2-[2-(2-Benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethylamine
• CAS No.: 86770-78-7
• Molecular Formula: C₁₉H₃₃NO₆
• Molecular Weight: 371.474
• Mol file: 86770-78-7.mol

Synonyms:2-[2-(2-{2-[2-(2-Benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethylamine

Chemical Property of 2-[2-(2-{2-[2-(2-Benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethylamine

Chemical Property:

• Boiling Point: 466.8±40.0 °C(Predicted)
• Density: 1.074±0.06 g/cm3(Predicted)

Purity/Quality:

95% ^*data from raw suppliers

BnO-PEG5-CH2CH2NH2 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(2-{2-[2-(2-Benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethylamine

There total 5 articles about 2-[2-(2-{2-[2-(2-Benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

{2-[2-(2-{2-[2-(2-Azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxymethyl}-benzene (86770-73-2) → 2-[2-(2-{2-[2-(2-Benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethylamine (86770-78-7)

Guidance literature:

With formiate d'ammonium; palladium on activated charcoal; In methanol; Ambient temperature;

DOI:10.1016/S0040-4039(00)81722-0

Reference yield:

pentaethylene glycol (2615-15-8) → 2-[2-(2-{2-[2-(2-Benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethylamine (86770-78-7)

Guidance literature:

Multi-step reaction with 4 steps

1: NaH / tetrahydrofuran / 12 h / Ambient temperature

2: pyridine / 0 °C

3: sodium azide / dimethylformamide / 12 h / 50 °C

4: 1.) PPh₃, 2.) H₂O / 1.) THF, RT, 12 h, 2.) RT, 12 h

With pyridine; sodium azide; water; sodium hydride; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja00091a005

Reference yield:

1-phenyl-2,5,8,11,14,17-hexaoxanonadecan-19-ol (24342-68-5,1201808-31-2) → 2-[2-(2-{2-[2-(2-Benzyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethylamine (86770-78-7)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 0 °C

2: sodium azide / dimethylformamide / 12 h / 50 °C

3: 1.) PPh₃, 2.) H₂O / 1.) THF, RT, 12 h, 2.) RT, 12 h

With pyridine; sodium azide; water; triphenylphosphine; In N,N-dimethyl-formamide;

DOI:10.1021/ja00091a005

upstream raw materials:

{2-[2-(2-{2-[2-(2-Azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxymethyl}-benzene

pentaethylene glycol

1-phenyl-2,5,8,11,14,17-hexaoxanonadecan-19-ol

19-Phenyl-3,6,9, 12,15,18-hexaoxanonadec-1-yl 4-methylbenzenesulfonate

Refernces

• 1、 Gartiser, T.,Selve, C.,Delpuech, J.-J.. "REDUCTION D'AZIDES EN AMINES PAR LE FORMIATE D'AMMONIUM PAR "TRANSFERT D'HYDROGENE CATALYSE" (CTH)". . p. 1609 - 1610. Retrieved 2007/10/02.