2,2-Diethoxyacetophenone

Base Information

• Chemical Name: 2,2-Diethoxyacetophenone
• CAS No.: 6175-45-7
• Deprecated CAS: 64131-70-0,85568-36-1,85568-36-1
• Molecular Formula: C12H16O3
• Molecular Weight: 208.257
• Hs Code.: Oral rat LD50: 5660 ul/kg
• European Community (EC) Number: 228-220-4
• NSC Number: 66180
• UNII: W4BCZ1MAK3
• DSSTox Substance ID: DTXSID1052294
• Nikkaji Number: J31.119G
• Wikidata: Q26841267
• Mol file: 6175-45-7.mol

Synonyms:2,2-DEAP;2,2-diethoxyacetophenone

Chemical Property of 2,2-Diethoxyacetophenone

Chemical Property:

• Appearance/Colour: clear yellow to salmon liquid
• Vapor Pressure: 0.01 mm Hg ( 20 °C)
• Refractive Index: NFPA RATINGS
• Boiling Point: 266.794 °C at 760 mmHg
• Flash Point: 125.549 °C
• PSA: 35.53000
• Density: 1.041 g/cm³
• LogP: 2.26840
• Storage Temp.: 2-8°C
• Water Solubility.: 0.16 g/L (25 ºC)
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 208.109944368
• Heavy Atom Count: 15
• Complexity: 179

Purity/Quality:

98%, ^*data from raw suppliers

2,2-Diethoxyacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-33-40
• Safety Statements: 23-24/25-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOC(C(=O)C1=CC=CC=C1)OCC
• Uses: It is an effective photoinitiator for UV-curable acrylate-based coatings, adhesives and inks. used in UV-curable system. Particularly useful for photo curing clear acrylate-based formulations where non-yellowing is important. It is also recommended for pigmented inks where shelf life and color stability are essential.

Technology Process of 2,2-Diethoxyacetophenone

There total 25 articles about 2,2-Diethoxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

ethanol (64-17-5) + α-(phenylseleno)acetophenone (35050-01-2) → 2,2-diethoxyacetophenone (6175-45-7)

Guidance literature:

With oxygen; toluene-4-sulfonic acid; copper(I) bromide; at 130 ℃; for 4h; Sealed tube;

DOI:10.1002/cjoc.202000089

Reference yield: 82.0%

2-ethoxyacetophenone (14869-39-7) + orthoformic acid triethyl ester (122-51-0) → 2,2-diethoxyacetophenone (6175-45-7)

Guidance literature:

With trifluorormethanesulfonic acid; [bis(acetoxy)iodo]benzene; at 20 ℃;

DOI:10.1002/chem.201603022

Reference yield: 81.0%

ethanol (64-17-5) + acetophenone (98-86-2) → 2,2-diethoxyacetophenone (6175-45-7)

Guidance literature:

With diphenyl diselenide; oxygen; toluene-4-sulfonic acid; copper(I) bromide; at 130 ℃; for 7h; Reagent/catalyst; Catalytic behavior; Sealed tube;

DOI:10.1002/cjoc.202000089

upstream raw materials:

diethoxyacetic acid piperidinyl amide

phenylglyoxal hydrate

1-phenyl-2,2-dimorpholin-1-yl-ethanone

ethanol

Downstream raw materials:

6-chloro-3-(hydroxy-phenyl-methyl)-1,1-dioxo-1,2(4)-dihydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide

6,7-dihydro-1-methyl-3-phenyl-1H-1,2,5-triazepine

5-phenyl-2-phenylthiopyrazine-3-carbonitrile

2-phenylacrylaldehyde diethyl acetal

Refernces

• 1、 Zhang, Li. "Modular Synthesis of α-Substituted Alkenyl Acetals by a Palladium-Catalyzed Suzuki Reaction of α-Haloalkenyl Acetals with Organoboranes". supporting information. p. 723 - 727. Retrieved 2021/02/26.
• 2、 Lyons,Crocker,Enders,Nguyen. "Tropylium salts as efficient organic Lewis acid catalysts for acetalization and transacetalization reactions in batch and flow". supporting information. p. 3993 - 3996. Retrieved 2017/09/08.