Multi-step reaction with 7 steps
1.1: water; sodium hydroxide / methanol / 40 - 50 °C
1.2: 15 - 20 °C / pH 4 - 4.2
2.1: ammonium chloride / acetonitrile / 1 h / 0 - 30 °C
3.1: 1,1'-carbonyldiimidazole / dichloromethane / 3 h / 0 - 25 °C
3.2: 10 h / 20 - 25 °C
4.1: sodium hypochlorite; sodium hydrogencarbonate; potassium bromide / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / water; ethyl acetate / 2 h / 0 - 5 °C / Inert atmosphere
5.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 70 - 75 °C
6.1: hydrogenchloride; water / acetonitrile / 16 h / 40 °C
7.1: water; sodium hydroxide / ethanol / 16 h / 20 - 25 °C
7.2: pH 3 - 4
7.3: 12 h / 20 - 25 °C
With
hydrogenchloride; sodium hypochlorite; water; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; 1,1'-carbonyldiimidazole; potassium bromide; sodium hydroxide;
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical;
In
methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;