Technology Process of 1-(2,3-dideoxy-2,3-difluoro-5-O-trityl-β-D-ribofuranosyl)uracil
There total 6 articles about 1-(2,3-dideoxy-2,3-difluoro-5-O-trityl-β-D-ribofuranosyl)uracil which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
diethylamino-sulfur trifluoride;
In
1,2-dichloro-ethane;
for 2h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 6.29 g / pyridine / 60 °C
2: 1.) trifluoromethanesulfonic anhydride, pyridine 2.) NaOH / 1.) CH2Cl2, 0 deg C, 2 h, 2.) dioxane, water, room temperature, overnight
3: 68 percent / diethylaminosulfur trifluoride / 1,2-dichloro-ethane / 2 h / Ambient temperature
With
pyridine; sodium hydroxide; diethylamino-sulfur trifluoride; trifluoromethanesulfonic acid anhydride;
In
1,2-dichloro-ethane;