N-(2-Furoyl)glycine

Base Information Edit

Chemical Name:N-(2-Furoyl)glycine
CAS No.:5657-19-2
Molecular Formula:C7H7 N O4
Molecular Weight:169.137
Hs Code.:2932190090
European Community (EC) Number:624-229-6
DSSTox Substance ID:DTXSID50205124
Nikkaji Number:J75.723C
Wikidata:Q27156454
Metabolomics Workbench ID:37249
ChEMBL ID:CHEMBL456404
Mol file:5657-19-2.mol

Synonyms:furoylglycine

Suppliers and Price of N-(2-Furoyl)glycine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Furoylglycine
100mg
$ 155.00

TRC
2-Furoylglycine
50mg
$ 95.00

TRC
2-Furoylglycine
2.5g
$ 860.00

Matrix Scientific
2-(2-Furoylamino)acetic acid
500mg
$ 237.00

Matrix Scientific
2-(2-Furoylamino)acetic acid
2.500g
$ 720.00

Crysdot
2-(Furan-2-carboxamido)aceticacid 95+%
250mg
$ 92.00

Atlantic Research Chemicals
2-(Furan-2-carboxamido)aceticacid 95%
100mgs:
$ 35.35

American Custom Chemicals Corporation
2-(2-FUROYLAMINO)ACETIC ACID 95.00%
2.5G
$ 1468.50

American Custom Chemicals Corporation
2-(2-FUROYLAMINO)ACETIC ACID 95.00%
500MG
$ 837.38

AK Scientific
2-(2-Furoylamino)aceticacid
250mg
$ 123.00

Total 8 raw suppliers

Chemical Property of N-(2-Furoyl)glycine Edit

Chemical Property:

Vapor Pressure:5.8E-08mmHg at 25°C
Melting Point:163-165 °C(lit.)
Boiling Point:440.6oC at 760 mmHg
PKA:3.66±0.10(Predicted)
Flash Point:220.3oC
PSA：79.54000
Density:1.28g/cm3
LogP:0.48490
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly)
XLogP3:-0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:169.03750770
Heavy Atom Count:12
Complexity:192

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Furoylglycine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1=COC(=C1)C(=O)NCC(=O)O
Uses 2-Furoylglycine is an intermediate used to prepare non-nucleoside inhibitors of HCV NS5b RNA polymerase. It is also used in the synthesis of benzimidazolylazabicyclooctylethylpiperidines as Ccr5 antagonists for the treatment of HIV infection.

Technology Process of N-(2-Furoyl)glycine

There total 2 articles about N-(2-Furoyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 527-69-5
2-furancarbonyl chloride

: 56-40-6,18875-39-3,25718-94-9
glycine

: 5657-19-2
N-(2-furoyl)-glycine

Guidance literature:: With sodium hydroxide; for 4h;
DOI:10.1016/0278-6915(94)90086-8

Reference yield:

: 88-14-2
2-furanoic acid

: 5657-19-2
N-(2-furoyl)-glycine

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride

2: alkali

With thionyl chloride;

Reference yield: 61.0%

: 5657-19-2
N-(2-furoyl)-glycine

: 138-37-4
mafenide hydrochloride

: N-(2-oxo-2-((4-sulfamoylbenzyl)amino)ethyl)furan-2-carboxamide

Guidance literature:: N-(2-furoyl)-glycine; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

mafenide hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1002/cmdc.202100510