1-Methylaziridine

Base Information

• Chemical Name: 1-Methylaziridine
• CAS No.: 1072-44-2
• Molecular Formula: C3H7 N
• Molecular Weight: 57.0953
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60147940
• Nikkaji Number: J132.785B
• Wikidata: Q83013374
• ChEMBL ID: CHEMBL2448851
• Mol file: 1072-44-2.mol

Synonyms:1-METHYLAZIRIDINE;Aziridine, 1-methyl-;N-Methylaziridine;N-Methylethylenimine;1-Methylethylenimine;1072-44-2;Methylaziridine, 1-;TL 37;BRN 0102381;5-20-01-00007 (Beilstein Handbook Reference);CHEMBL2448851;DTXSID60147940;LS-23273

Chemical Property of 1-Methylaziridine

Chemical Property:

• Vapor Pressure: 692mmHg at 25°C
• Refractive Index: 1.3885 (estimate)
• Boiling Point: 27.5°Cat760mmHg
• PKA: 7.80±0.20(Predicted)
• Flash Point: °C
• PSA: 3.01000
• Density: 0.887g/cm³
• LogP: -0.13030
• XLogP3: 0
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 57.057849228
• Heavy Atom Count: 4
• Complexity: 22.5

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Amines, Aliphatic
• Canonical SMILES: CN1CC1

Technology Process of 1-Methylaziridine

There total 12 articles about 1-Methylaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

N-Methyltaurine (107-68-6) → N-methylaziridine (1072-44-2)

Guidance literature:

With sodium hydroxide; Heating;

DOI:10.1021/ja00003a021

Reference yield: 29.3%

(2-hydroxyethyl)(methyl)amine (109-83-1) → N-methylaziridine (1072-44-2)

Guidance literature:

With chlorosulfonic acid; at 140 - 150 ℃; for 2h; under 20 Torr;

DOI:10.1021/jo00060a027

Reference yield:

1-methyltriazoline (136911-37-0) → N-methylaziridine (1072-44-2) + (2-hydroxyethyl)(methyl)amine (109-83-1) + acetaldehyde (75-07-0,9002-91-9) + methylamine (74-89-5)

Guidance literature:

With water; at 25 ℃; Rate constant; Product distribution; Mechanism; pH 10.75 (lysine buffer); other solvent, other pH (other buffers), H/D isotope effect;

DOI:10.1021/jo00060a027

upstream raw materials:

sulfuric acid mono-(2-methylamino-ethyl) ester

(2-hydroxyethyl)(methyl)amine

N-Methyltaurine

1-methyltriazoline

Downstream raw materials:

N-Methyl-N-(2-chlorethyl)-2,6-dinitro-4-(trifluormethyl)anilin

(2-hydroxyethyl)(methyl)amine

methane

hydrogen cyanide

Refernces

• 1、 -. "Metastin derivatives and use thereof". . . Retrieved 2009/09/07.
• 2、 Atagi, Lauren M.,Over, Diana E.,McAlister, Donald R.,Mayer, James M.. "On the mechanism of oxygen atom or nitrene group transfer in reactions of epoxides and aziridines with tungsten(II) compounds". . p. 870 - 874. Retrieved 2007/10/02.