4-Acetylphenyloxooxazolidinylmethylacetamide

Base Information Edit

Chemical Name:4-Acetylphenyloxooxazolidinylmethylacetamide
CAS No.:104421-21-8
Molecular Formula:C14H16 N2 O4
Molecular Weight:276.292
Hs Code.:
DSSTox Substance ID:DTXSID70908968
Nikkaji Number:J468.721C
Mol file:104421-21-8.mol

Synonyms:4-acetylphenyloxooxazolidinylmethylacetamide;DuP 721;DuP-721

Suppliers and Price of 4-Acetylphenyloxooxazolidinylmethylacetamide

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 4-Acetylphenyloxooxazolidinylmethylacetamide Edit

Chemical Property:

Vapor Pressure:4.01E-11mmHg at 25°C
Boiling Point:525.2°Cat760mmHg
Flash Point:271.4°C
PSA：75.71000
Density:1.238g/cm³
LogP:1.80640
XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:276.11100700
Heavy Atom Count:20
Complexity:402

Purity/Quality:: 99%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1=CC=C(C=C1)N2CC(OC2=O)CNC(=O)C

Technology Process of 4-Acetylphenyloxooxazolidinylmethylacetamide

There total 11 articles about 4-Acetylphenyloxooxazolidinylmethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 108-24-7
acetic anhydride

: 114992-59-5
(S)-N-<5-aminomethyl-3-(4-acetylphenyl)-2-oxooxazolidine>hydrochloride

: 104421-21-8
N-[(S)-3-(4-Acetyl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; water; for 0.5h; Ambient temperature;
DOI:10.1016/0040-4020(89)80130-9

Reference yield: 65.0%

: 352524-62-0
N-[3-(4-acetyl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-N-(2,4-dimethoxy-benzyl)-acetamide

: 104421-21-8
N-[(S)-3-(4-Acetyl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0040-4039(01)00559-7

Reference yield:

: 49647-20-3
4-acetylphenyl isocyanate

: 104421-21-8
N-[(S)-3-(4-Acetyl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1: 82 percent / LiBr, n-Bu₃PO / xylene / 2 h / Heating

2: 100 percent / sodium methoxide / methanol / 2 h / Ambient temperature

3: 96 percent / pyridine / 15 °C

4: 94 percent / NaI / acetone / 18 h / Heating

5: 70 percent / Et₃N / tetrahydrofuran / 18 h / Heating

6: 87 percent / sodium azide, 18-crown-6 / dimethylformamide / 5 h / 70 °C

7: 82 percent / trimethyl phosphite / 1,2-dimethoxy-ethane / 1.5 h / Heating

8: 70 percent / NaOH / H₂O; tetrahydrofuran / 0 - 5 °C

With pyridine; sodium hydroxide; sodium azide; 18-crown-6 ether; Tributylphosphine oxide; sodium methylate; triethylamine; sodium iodide; lithium bromide; phosphorous acid trimethyl ester; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetone; xylene;
DOI:10.1021/jm00128a003