N-Acetyl-3.4.5-trimethoxyphenylalanin

Base Information

• Chemical Name: N-Acetyl-3.4.5-trimethoxyphenylalanin
• CAS No.: 82337-59-5
• Molecular Formula: C₁₄H₁₉NO₆
• Molecular Weight: 297.308
• Mol file: 82337-59-5.mol

Synonyms:N-Acetyl-3.4.5-trimethoxyphenylalanin

Chemical Property of N-Acetyl-3.4.5-trimethoxyphenylalanin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-Acetyl-3.4.5-trimethoxyphenylalanin

There total 5 articles about N-Acetyl-3.4.5-trimethoxyphenylalanin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

α-acetamido-3,4,5-trimethoxycinnamic acid (87293-13-8) → N-Acetyl-3.4.5-trimethoxyphenylalanin (82337-59-5,18111-20-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/ja00226a035

Reference yield:

3,4,5-trimethoxy-benzaldehyde (86-81-7) → N-Acetyl-3.4.5-trimethoxyphenylalanin (82337-59-5,18111-20-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / acetic anhydride, NaOAc / acetic acid / 1.) 80 deg C, 20 min, 2.) 143 deg C, 1 h

2: 62 percent / water / acetone / Heating

3: 95 percent / H₂ / 5 percent Pd/C / methanol

With water; hydrogen; sodium acetate; acetic anhydride; palladium on activated charcoal; In methanol; acetic acid; acetone;

DOI:10.1021/ja00226a035

Reference yield:

2-methyl-4-(3,4,5-trimethoxyphenylmethylene)-5(4H)-oxazolone (92249-24-6) → N-Acetyl-3.4.5-trimethoxyphenylalanin (82337-59-5,18111-20-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / water / acetone / Heating

2: 95 percent / H₂ / 5 percent Pd/C / methanol

With water; hydrogen; palladium on activated charcoal; In methanol; acetone;

DOI:10.1021/ja00226a035

upstream raw materials:

Diethyl-α-acetamido-α-<3,4,5-trimethoxy-benzyl>-malonat

α-acetamido-3,4,5-trimethoxycinnamic acid

3,4,5-trimethoxy-benzaldehyde

2-methyl-4-(3,4,5-trimethoxyphenylmethylene)-5(4H)-oxazolone

Downstream raw materials:

(R)-methyl 2-acetamido-3-(3,4,5-trimethoxyphenyl)propanoate

(R)-2-Amino-3-(3,4,5-trimethoxy-phenyl)-propionic acid; hydrochloride

(R)-2-((tert-butoxycarbonyl)amino)-3-(3,4,5-trimethoxyphenyl)propanoic acid

2-Amino-3-(3,4,5-trimethoxy-phenyl)-propionic acid; hydrochloride

Refernces