2-(2-azidoethyl)-5-nitrophenethyl methanesulfonate

Base Information

• Chemical Name: 2-(2-azidoethyl)-5-nitrophenethyl methanesulfonate
• CAS No.: 1016265-84-1
• Molecular Formula: C₁₁H₁₄N₄O₅S
• Molecular Weight: 314.322
• Mol file: 1016265-84-1.mol

Synonyms:2-(2-azidoethyl)-5-nitrophenethyl methanesulfonate

Chemical Property of 2-(2-azidoethyl)-5-nitrophenethyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-azidoethyl)-5-nitrophenethyl methanesulfonate

There total 4 articles about 2-(2-azidoethyl)-5-nitrophenethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2'-(4-nitro-1,2-phenylene)bis(ethane-2,1-diyl) dimethanesulfonate (176492-82-3) → 2-(2-azidoethyl)-4-nitrophenethyl methanesulfonate (1016265-86-3) + 2-(2-azidoethyl)-5-nitrophenethyl methanesulfonate (1016265-84-1)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; for 4h;

Reference yield:

1,2-Phenylenediacetic acid (7500-53-0) → 2-(2-azidoethyl)-4-nitrophenethyl methanesulfonate (1016265-86-3) + 2-(2-azidoethyl)-5-nitrophenethyl methanesulfonate (1016265-84-1)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid; nitric acid / 4 h / 0 °C

2: borane-THF / tetrahydrofuran / 2 h / 0 °C

3: triethylamine / dichloromethane / 3 h / 0 °C

4: sodium azide / N,N-dimethyl-formamide / 20 °C

With sodium azide; borane-THF; sulfuric acid; nitric acid; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

2,2'-(4-nitro-1,2-phenylene)diacetic acid (176492-85-6) → 2-(2-azidoethyl)-4-nitrophenethyl methanesulfonate (1016265-86-3) + 2-(2-azidoethyl)-5-nitrophenethyl methanesulfonate (1016265-84-1)

Guidance literature:

Multi-step reaction with 3 steps

1: borane-THF / tetrahydrofuran / 2 h / 0 °C

2: triethylamine / dichloromethane / 3 h / 0 °C

3: sodium azide / N,N-dimethyl-formamide / 20 °C

With sodium azide; borane-THF; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2,2'-(4-nitro-1,2-phenylene)bis(ethane-2,1-diyl) dimethanesulfonate

1,2-Phenylenediacetic acid

2,2'-(4-nitro-1,2-phenylene)diacetic acid

Downstream raw materials:

2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamine

Refernces

• 1、 -. "USE OF ION CHANNEL MODULATORS IN THE PROPHYLAXIS AND TREATMENT OF INFLAMMATORY AND IMMUNOLOGICAL DISEASES". Page/Page column 33. . Retrieved 2010/11/30.