Technology Process of 1D-(1,3,6/2)-6-azido-4-benzyloxymethyl-1,2,3-tri-O-benzyltrihydroxycyclohex-4-ene
There total 7 articles about 1D-(1,3,6/2)-6-azido-4-benzyloxymethyl-1,2,3-tri-O-benzyltrihydroxycyclohex-4-ene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium azide;
In
N,N-dimethyl-formamide;
at 50 ℃;
for 3h;
- Guidance literature:
-
(1R,2S,3S,4R)-2,3,4-tri-O-benzyl-5-(benzyloxymethyl)-cyclohex-5-ene-1,2,3,4-tetrol;
With
diphenylphosphoranyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
toluene;
at 0 - 20 ℃;
for 7h;
With
sodium azide;
In
toluene;
at 20 ℃;
for 12h;
Further stages.;
DOI:10.1021/ja005746b
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) Mg, HgCl2 / 1.) THF, 3 h, 0 deg C; 2.) -78 deg C to 0 deg C
2: 81 percent / SOCl2 / diethyl ether / 5 h / Heating
3: 83 percent / NaN3 / dimethylformamide / 3 h / 50 °C
With
thionyl chloride; sodium azide; magnesium; mercury dichloride;
In
diethyl ether; N,N-dimethyl-formamide;