C₁₈H₁₀ClF₃N₄O₂

Base Information

• Chemical Name: C₁₈H₁₀ClF₃N₄O₂
• CAS No.: 1374423-68-3
• Molecular Formula: C₁₈H₁₀ClF₃N₄O₂
• Molecular Weight: 406.751
• Mol file: 1374423-68-3.mol

Synonyms:C₁₈H₁₀ClF₃N₄O₂

Chemical Property of C₁₈H₁₀ClF₃N₄O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₈H₁₀ClF₃N₄O₂

There total 5 articles about C₁₈H₁₀ClF₃N₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

nicotinic acid (59-67-6) → C18H10ClF3N4O2 (1374423-68-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 18 h / 90 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran; toluene / 1 h / 0 °C

2.2: 10 h / 20 °C

3.1: Oxone / methanol / 5 h / 0 - 20 °C

4.1: sodium hydride / tetrahydrofuran / 5 h / Reflux

With Oxone; isopropylmagnesium chloride; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;

DOI:10.5012/bkcs.2011.32.4.1209

Reference yield:

(2-methylthiopyrimidin-4-yl)(pyridin-3-yl)methanone (1314678-26-6) → C18H10ClF3N4O2 (1374423-68-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Oxone / methanol / 5 h / 0 - 20 °C

2: sodium hydride / tetrahydrofuran / 5 h / Reflux

With Oxone; sodium hydride; In tetrahydrofuran; methanol;

DOI:10.5012/bkcs.2011.32.4.1209

Reference yield:

N-methoxy-N-methylpyridine-3-carboxamide (95091-91-1) → C18H10ClF3N4O2 (1374423-68-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran; toluene / 1 h / 0 °C

1.2: 10 h / 20 °C

2.1: Oxone / methanol / 5 h / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran / 5 h / Reflux

With Oxone; isopropylmagnesium chloride; sodium hydride; In tetrahydrofuran; methanol; toluene;

DOI:10.5012/bkcs.2011.32.4.1209

upstream raw materials:

nicotinic acid

(2-methylthiopyrimidin-4-yl)(pyridin-3-yl)methanone

(2-methylsulfonylpyrimidin-4-yl)(pyridin-3-yl)methanone

4-chloro-3-(trifluoromethyl)phenylamino aldehyde

Downstream raw materials:

(2-(4-chloro-3-trifluoromethylphenylamino)pyrimidin-4-yl)(pyridin-3-yl)methanone

Refernces