(7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate

Base Information

• Chemical Name: (7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate
• CAS No.: 156311-83-0
• Molecular Formula: C17H27N7OP^.PF6
• Molecular Weight: 521.38
• Hs Code.: 29339900
• European Community (EC) Number: 627-192-4
• UNII: C5Z532MU8E
• DSSTox Substance ID: DTXSID00935424
• Wikipedia: PyAOP_reagent
• Wikidata: Q21099614
• Mol file: 156311-83-0.mol

Synonyms:156311-83-0;PyAOP;(7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate;((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V);(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate;PYAOP REAGENT;tripyrrolidin-1-yl(triazolo[4,5-b]pyridin-3-yloxy)phosphanium;hexafluorophosphate;MFCD03703417;hexafluoro-lambda5-phosphanuide;tris(pyrrolidin-1-yl)({3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy})phosphanium;O-(1,2-Dihydro-2-oxo-pyridyl]-N,N,N inverted exclamation mark(R),N inverted exclamation mark(R)-tetramethyluronium hexafluorophosphate;Phosphorus(1+), (3-hydroxy-3H-1,2,3-triazolo(4,5-b)pyridinato-O)tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-);((7-Azabenzotriazol-1-yl)oxy)tris(pyrrolidino)phosphonium hexafluorophosphate;[(7-Azabenzotriazol-1-yl)oxy]tris(pyrrolidino)phosphonium hexafluorophosphate;(3-hydroxy-3h-1,2,3-triazolo(4,5-b)pyridinato-o)tri-1-pyrrolidinylphosphonium hexafluorophosphate;PHOSPHORUS(1+), (3-(HYDROXY-.KAPPA.O)-3H-1,2,3-TRIAZOLO(4,5-B)PYRIDINATO)TRI-1-PYRROLIDINYL-, (T-4)-, HEXAFLUOROPHOSPHATE(1-) (1:1);Phosphorus(1+), [3-(hydroxy-.kappa.O)-3H-1,2,3-triazolo[4,5-b]pyridinato]tri-1-pyrrolidinyl-, (T-4)-, hexafluorophosphate(1-) (1:1);(7-azabenzotriazol-1-yloxy)tripyrrolidino-phosphonium hexafluorophosphate;C17H27N7OP.F6P;C5Z532MU8E;SCHEMBL19474888;DTXSID00935424;CBZAHNDHLWAZQC-UHFFFAOYSA-N;BCP01269;AC-085;7-azabenzotriazol-1-yloxy-tris-(pyrrolidino)phosphonium hexafluorophosphate;AKOS016002878;AM83840;CS-W011482;GS-3263;C17-H27-N7-O-P.F6-P;SY019060;FT-0654823;EN300-7492597;A809733;J-501219;Q21099614;7-azabenzotriazol-1-yloxy-tris(pyrrolidino)phosphonium hexafluorophosphate;7-azabenzotriazol-1-yloxytris(pyrrolidino)phosphonium hexafluorophos-phate;7-azabenzotriazol-1-yloxytris(pyrrolidino)phosphonium hexafluorophosphate;(7-Aza-1H-benzotriazol-1-yloxy)tri(1-pyrrolidinyl)phosphonium hexafluorophosphate;(7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate, 96%;((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate;((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphoniumhexafluorophosphate(V);(3h-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)tripyrrolidin-1-ylphosphonium hexafluorophosphate(v);PHOSPHONIUM, TRI-1-PYRROLIDINYL(3H-1,2,3-TRIAZOLO(4,5-B)PYRIDIN-3-YLOXY)-, HEXAFLUOROPHOSPHATE(1-)

Chemical Property of (7-Azabenzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate

Chemical Property:

• Melting Point: 163-168 °C(lit.)
• PSA: 89.73000
• LogP: 5.41600
• Storage Temp.: ?20°C
• Water Solubility.: Soluble in water.
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 5
• Exact Mass: 521.16565148
• Heavy Atom Count: 33
• Complexity: 502

Purity/Quality:

99% ^*data from raw suppliers

PyAOP ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CCN(C1)[P+](N2CCCC2)(N3CCCC3)ON4C5=C(C=CC=N5)N=N4.F[P-](F)(F)(F)(F)F
• Uses: (3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate is used as a coupling reagent in solid phase peptide synthesis. It is preferred over HATU, because it does not side react at the N-terminus of the peptide. Compared to the HOBt derivates, PyAOP (and HOAt in general) are more reactive due to the additional nitrogen. PyAOP is a phosphonium salt used as a coupling reagent in solid-phase peptide synthesis, without undergoing side reactions with the amino terminus. PyAOP is a derivative of HOAt (H805070).