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Econazole

Base Information Edit
  • Chemical Name:Econazole
  • CAS No.:27220-47-9
  • Deprecated CAS:68797-30-8
  • Molecular Formula:C18H15Cl3N2O
  • Molecular Weight:381.689
  • Hs Code.:
  • European Community (EC) Number:248-341-6
  • NSC Number:187789
  • UNII:6Z1Y2V4A7M
  • DSSTox Substance ID:DTXSID2029872
  • Nikkaji Number:J10.724G,J304.909D,J306.630D
  • Wikipedia:Econazole
  • Wikidata:Q417141
  • NCI Thesaurus Code:C61740
  • RXCUI:3743
  • Pharos Ligand ID:PCDF78AF18JM
  • Metabolomics Workbench ID:43352
  • ChEMBL ID:CHEMBL808
  • Mol file:27220-47-9.mol
Econazole

Synonyms:Econazole;Econazole Nitrate;Ekonazole;Gyno Pervaryl 150;Gyno Pevaril;Gyno Pevaryl;Gyno-Pervaryl 150;Gyno-Pevaril;Gyno-Pevaryl;GynoPevaril;Nitrate, Econazole;Pevaryl

Suppliers and Price of Econazole
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Econazole
  • 2.5g
  • $ 395.00
  • Sigma-Aldrich
  • Econazole European Pharmacopoeia (EP) Reference Standard
  • $ 190.00
  • Sigma-Aldrich
  • Econazole European Pharmacopoeia (EP) Reference Standard
  • y0001236
  • $ 190.00
  • Crysdot
  • Econazole 97+%
  • 100mg
  • $ 89.00
  • ChemScene
  • Econazole 99.37%
  • 500mg
  • $ 50.00
  • AvaChem
  • Econazole
  • 10g
  • $ 75.00
  • AvaChem
  • Econazole
  • 1g
  • $ 35.00
  • American Custom Chemicals Corporation
  • ECONAZOLE 95.00%
  • 10G
  • $ 1408.01
  • American Custom Chemicals Corporation
  • ECONAZOLE 95.00%
  • 1G
  • $ 148.05
  • Ambeed
  • 1-(2-((4-Chlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole 97+%
  • 100g
  • $ 95.00
Total 97 raw suppliers
Chemical Property of Econazole Edit
Chemical Property:
  • Melting Point:86.8 °C 
  • Boiling Point:533.8 °C at 760 mmHg 
  • PKA:6.68±0.12(Predicted) 
  • Flash Point:276.6 °C 
  • PSA:27.05000 
  • Density:1.33 g/cm3 
  • LogP:5.80140 
  • Storage Temp.:Sealed in dry,Room Temperature 
  • Solubility.:Practically insoluble in water, very soluble in ethanol (96 per cent) and in methylene chloride. 
  • Water Solubility.:0.37g/L(ambient temperature) 
  • XLogP3:5.3
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:2
  • Rotatable Bond Count:6
  • Exact Mass:380.024996
  • Heavy Atom Count:24
  • Complexity:379
Purity/Quality:

99%, *data from raw suppliers

Econazole *data from reagent suppliers

Safty Information:
  • Pictogram(s): IrritantXi 
  • Hazard Codes:Xi 
  • Statements: 36/37/38 
  • Safety Statements: 24/25-36/37/39 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
  • Uses antineoplastic, anti-estrogen. Econazole (Spectazole) is a synthetic imidazole. Econazole blocks C-14 demethylation of sterols, interfering with the biosynthesis of ergosterol, which results in disorganization of the fungal plasma cell membrane and increased permeability. It is active against dermatophytes, yeast, P. orbiculare, Aspergillus, Cladosporium, and Sporothrix. Econazole (cas# 27220-47-9) is a compound useful in organic synthesis.
  • Indications Econazole (Spectazole) is a synthetic imidazole. Econazole blocks C-14 demethylation of sterols, interfering with the biosynthesis of ergosterol, which results in disorganization of the fungal plasma cell membrane and increased permeability. It is active against dermatophytes, yeast, P. orbiculare, Aspergillus, Cladosporium, and Sporothrix.
  • Therapeutic Function Antifungal
Technology Process of Econazole

There total 7 articles about Econazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol; With sodium hydride; In N,N-dimethyl-formamide; at -5 - 20 ℃; for 1.5h; Inert atmosphere;
4-chlorobenzyl halide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2018.02.014
Guidance literature:
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / methanol / 20 °C
2: potassium iodide / acetonitrile / Reflux
With sodium tetrahydroborate; potassium iodide; In methanol; acetonitrile;
DOI:10.1039/C6SC05368H
Guidance literature:
Multi-step reaction with 3 steps
1: potassium carbonate / acetonitrile
2: sodium tetrahydroborate / methanol / 20 °C
3: potassium iodide / acetonitrile / Reflux
With sodium tetrahydroborate; potassium carbonate; potassium iodide; In methanol; acetonitrile;
DOI:10.1039/C6SC05368H
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