N-(5-CHLORO-4-METHYL-2-NITROPHENYL)ACETAMIDE

Base Information

• Chemical Name: N-(5-CHLORO-4-METHYL-2-NITROPHENYL)ACETAMIDE
• CAS No.: 7149-78-2
• Molecular Formula: C9H9ClN2O3
• Molecular Weight: 228.635
• Hs Code.: 2924299090
• Mol file: 7149-78-2.mol

Synonyms:6-Chlor-3-nitro-4-acetamino-toluol;5-chloro-4-methyl-2-nitroacetanilide;Essigsaeure-(5-chlor-4-methyl-2-nitro-anilid);chloromethylnitrophenylacetamide;N-Acetyl-5-chlor-2-nitro-p-toluidin;acetic acid-(5-chloro-4-methyl-2-nitro-anilide);

Chemical Property of N-(5-CHLORO-4-METHYL-2-NITROPHENYL)ACETAMIDE

Chemical Property:

• Vapor Pressure: 6.02E-07mmHg at 25°C
• Melting Point: 104-105oC
• Boiling Point: 410.4°C at 760 mmHg
• PKA: 13.17±0.70(Predicted)
• Flash Point: 202°C
• PSA: 74.92000
• Density: 1.406g/cm³
• LogP: 3.11120

Purity/Quality:

98%min ^*data from raw suppliers

4-Acetamido-2-chloro-5-nitrotoluene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(5-CHLORO-4-METHYL-2-NITROPHENYL)ACETAMIDE

There total 4 articles about N-(5-CHLORO-4-METHYL-2-NITROPHENYL)ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-(3-chloro-4-methylphenyl)acetamide (7149-79-3) → 5-chloro-4-methyl-2-nitroacetanilide (7149-78-2)

Guidance literature:

With sulfuric acid; potassium nitrate; at 5 ℃;

Reference yield:

3-chloro-p-toluidine (95-74-9,827571-80-2) → 5-chloro-4-methyl-2-nitroacetanilide (7149-78-2)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; triethylamine / ethyl acetate / 6 h / 0 - 20 °C

2: nitric acid; acetic anhydride / acetic acid / 5 h / -10 - 20 °C

With dmap; nitric acid; acetic anhydride; triethylamine; In acetic acid; ethyl acetate;

Reference yield:

N-(3-chloro-4-methylphenyl)acetamide (7149-79-3) + nitric acid (7697-37-2,78989-43-2) → 5-chloro-4-methyl-2-nitroacetanilide (7149-78-2)

Guidance literature:

upstream raw materials:

N-(3-chloro-4-methylphenyl)acetamide

nitric acid

3-chloro-p-toluidine

Downstream raw materials:

4-amino-2-cyclopropyl-5-nitrotoluene

2-(5-chloro-4-methyl-2-nitrophenylamino)tetrahydropyran-3,4,5-triol

ethyl 7-(2-amino-5-chloro-4-methylphenylamino)heptanoate

(2R,3S,4S)-5-(2-amino-5-chloro-4-methylphenylamino)pentane-1,2,3,4-tetraol

Refernces

• 1、 -. "FLAVIN DERIVATIVES". Page/Page column 167. . Retrieved 2010/04/03.