Furazabol

Base Information

• Chemical Name: Furazabol
• CAS No.: 1239-29-8
• Molecular Formula: C20H30N2O2
• Molecular Weight: 330.47
• European Community (EC) Number: 214-983-0
• UNII: 2W07HSP5PX
• DSSTox Substance ID: DTXSID7046889
• Nikkaji Number: J868K
• Wikipedia: Furazabol
• Wikidata: Q411537
• NCI Thesaurus Code: C65782
• Metabolomics Workbench ID: 146164
• ChEMBL ID: CHEMBL1893554
• Mol file: 1239-29-8.mol

Synonyms:1H-Cyclopenta[7,8]phenanthro[2,3-c][1,2,5]oxadiazol-1-ol,2,3,3aa,3bb,4,5,5aa,6,10,10a,10ba,11,12,12a-tetradecahydro-1a,10ab,12ab-trimethyl- (7CI);5a-Androstano[2,3-c][1,2,5]oxadiazol-17b-ol, 17-methyl- (8CI);17-Methyl-5a-androstano[2,3-c]furazan-17b-ol;5a-Androstano[2,3-c]furazan-17b-ol, 17-methyl-;Frazalon;

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Furazabol

Chemical Property:

• Vapor Pressure: 1.01E-08mmHg at 25°C
• Melting Point: 152-153°
• Refractive Index: 1.549
• Boiling Point: 445.569 °C at 760 mmHg
• PKA: 15.14±0.60(Predicted)
• Flash Point: 223.273 °C
• PSA: 59.15000
• Density: 1.145 /cm³
• LogP: 3.77800
• XLogP3: 4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 330.230728204
• Heavy Atom Count: 24
• Complexity: 542

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC12CCC3C(C1CCC2(C)O)CCC4C3(CC5=NON=C5C4)C
• Isomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C)O)CC[C@@H]4[C@@]3(CC5=NON=C5C4)C
• Uses: Furazabol is an anabolic steroid with hypocholesterolemic properties. This is a controlled substance (anabolic steroid).
• Therapeutic Function: Anticholesteremic

Technology Process of Furazabol

There total 5 articles about Furazabol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

17β-hydroxy-17α-methyl-(5α)-androstane-2,3-dione dioxime (3137-81-3) → Frazalon (1239-29-8)

Guidance literature:

With potassium hydroxide; In ethylene glycol; at 180 - 190 ℃;

DOI:10.1248/cpb.13.1445

Reference yield:

mestanolone (521-11-9,7241-35-2) → Frazalon (1239-29-8)

Guidance literature:

Multi-step reaction with 3 steps

1: O₂, KOtBu / 2-methyl-propan-2-ol

2: aq. NH₂OH*HCl

3: KOH / ethane-1,2-diol / 180 - 190 °C

With potassium hydroxide; hydroxylamine hydrochloride; potassium tert-butylate; oxygen; In ethylene glycol; tert-butyl alcohol;

DOI:10.1248/cpb.13.1445

Reference yield:

17β-Hydroxy-17α-methyl-androstan-2,3-dion (1162-87-4) → Frazalon (1239-29-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NH₂OH*HCl

2: KOH / ethane-1,2-diol / 180 - 190 °C

With potassium hydroxide; hydroxylamine hydrochloride; In ethylene glycol;

DOI:10.1248/cpb.13.1445

upstream raw materials:

17β-hydroxy-17α-methyl-(5α)-androstane-2,3-dione dioxime

mestanolone

17β-Hydroxy-17α-methyl-androstan-2,3-dion

2-Hydroxylimino-17β-hydroxy-17α-methyl-androstan-3-on

Downstream raw materials:

17α-methyl-17β-(3-phenyl-propionyloxy)-(5α)-androstano[2,3-c][1,2,5]oxadiazole

Refernces

• 1、 Ohta,Takegoshi,Ueno,Shimizu. "Investigations on steroids. IV. Syntheses of androstano[2,3-c]furazans and related compounds.". . p. 1445 - 1459. Retrieved 2007/10/06.