3-benzyloxy-6-aminophenanthridine

Base Information

• Chemical Name: 3-benzyloxy-6-aminophenanthridine
• CAS No.: 1207463-27-1
• Molecular Formula: C₂₀H₁₆N₂O
• Molecular Weight: 300.36
• Mol file: 1207463-27-1.mol

Synonyms:3-benzyloxy-6-aminophenanthridine

Chemical Property of 3-benzyloxy-6-aminophenanthridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-benzyloxy-6-aminophenanthridine

There total 2 articles about 3-benzyloxy-6-aminophenanthridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

5-(Benzyloxy)-2-bromophenylamine (119879-90-2) + 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (214360-48-2) → 3-benzyloxy-6-aminophenanthridine (1207463-27-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; for 12h; Inert atmosphere; Reflux;

DOI:10.1021/bc900314n

Reference yield:

2-Chlorobenzonitrile (873-32-5) + 3-(benzyloxy)aniline (1484-26-0) → 1-benzyloxy-6-aminophenanthridine (1207463-25-9) + 3-benzyloxy-6-aminophenanthridine (1207463-27-1)

Guidance literature:

3-(benzyloxy)aniline; With ammonia; sodium; ferric nitrate; In diethyl ether; for 0.5h;

2-Chlorobenzonitrile; In diethyl ether; for 2h;

With lithium; In diethyl ether; for 2h;

DOI:10.1021/bc900314n

Reference yield: 83.0%

phthalic anhydride (85-44-9) + 3-benzyloxy-6-aminophenanthridine (1207463-27-1) → 2-(3-benzyloxyphenanthridin-6-yl)-isoindole-1,3-dione (1207463-30-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; for 6h; Reflux;

DOI:10.1021/bc900314n

upstream raw materials:

2-Chlorobenzonitrile

3-(benzyloxy)aniline

5-(Benzyloxy)-2-bromophenylamine

2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

Downstream raw materials:

2-(3-benzyloxyphenanthridin-6-yl)-isoindole-1,3-dione

Refernces