Technology Process of Toluene-4-sulfonic acid 4-ethyl-4-hydroxy-hexyl ester
There total 1 articles about Toluene-4-sulfonic acid 4-ethyl-4-hydroxy-hexyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
-
-
(5Z,7E)-(1S,2S,3R,20R)-24,26,27-trihomo-2-methyl-22-oxa-9,10-seco-5,7,10(19)-cholestatriene-1,3,25-triol
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 2,6-lutidine / 1 h / 0 °C
2: 92 percent / NaI / dimethylformamide / 6 h / 20 °C
3: 86 percent / KH; 18-crown-6 / tetrahydrofuran / 20 °C
4: 81 percent / TFA / CH2Cl2 / 0.75 h / 0 °C
5: 80 percent / 4 Angstroem molecular sieves; PDC / CH2Cl2 / 1 h / 20 °C
6: 33 percent / NaHMDS / tetrahydrofuran / -60 - 20 °C
7: (dba)3Pd2*CHCl3; Ph3P; Et3N / toluene / 6 h / Heating
8: 6 percent / CSA / methanol / 20 °C
With
2,6-dimethylpyridine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; dipyridinium dichromate; 18-crown-6 ether; 4 A molecular sieve; camphor-10-sulfonic acid; sodium hexamethyldisilazane; potassium hydride; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium iodide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
1: silylation / 2: substitution / 3: etherification / 4: hydrolysis / 5: oxidation / 6: Wittig reaction / 7: cyclocondensation / 8: hydrolysis;
DOI:10.1016/S0968-0896(00)00267-4
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 2,6-lutidine / 1 h / 0 °C
2: 92 percent / NaI / dimethylformamide / 6 h / 20 °C
3: 86 percent / KH; 18-crown-6 / tetrahydrofuran / 20 °C
4: 81 percent / TFA / CH2Cl2 / 0.75 h / 0 °C
5: 80 percent / 4 Angstroem molecular sieves; PDC / CH2Cl2 / 1 h / 20 °C
6: 33 percent / NaHMDS / tetrahydrofuran / -60 - 20 °C
7: (dba)3Pd2*CHCl3; Ph3P; Et3N / toluene / 6 h / Heating
With
2,6-dimethylpyridine; tris(dibenzylideneacetone)dipalladium(0) chloroform complex; dipyridinium dichromate; 18-crown-6 ether; 4 A molecular sieve; sodium hexamethyldisilazane; potassium hydride; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium iodide;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
1: silylation / 2: substitution / 3: etherification / 4: hydrolysis / 5: oxidation / 6: Wittig reaction / 7: cyclocondensation;
DOI:10.1016/S0968-0896(00)00267-4