Cbz-glycylphenylalanylglycine

Base Information

• Chemical Name: Cbz-glycylphenylalanylglycine
• CAS No.: 2541-29-9
• Molecular Formula: C₂₁H₂₃N₃O₆
• Molecular Weight: 413.43
• Mol file: 2541-29-9.mol

Synonyms:Cbz-glycylphenylalanylglycine

Chemical Property of Cbz-glycylphenylalanylglycine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cbz-glycylphenylalanylglycine

There total 7 articles about Cbz-glycylphenylalanylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl Cbz-glycylphenylalanylglycinate (10144-74-8) → Cbz-glycylphenylalanylglycine (2541-29-9)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2019.151311

Reference yield:

Z-Gly-(L)-Phe (1170-76-9) + isobutyl chloroformate (543-27-1) → Cbz-glycylphenylalanylglycine (2541-29-9)

Guidance literature:

With tetrahydrofuran; triethylamine; anschliessendes Behandeln mit Glycin und wss. NaOH;

DOI:10.1021/ja01118a025

Reference yield:

Z-Gly-(L)-Phe (1170-76-9) → Cbz-glycylphenylalanylglycine (2541-29-9)

Guidance literature:

With sulfur trioxide-N,N-dimethylformamide complex; N,N-dimethyl-formamide; anschliessendes Behandeln mit Glycin und wss. NaOH;

upstream raw materials:

Z-Gly-(L)-Phe

N-(N-benzyloxycarbonyl-glycyl)-L-thiophenylalanine S-(4-nitro-phenyl ester)

glycine

isobutyl chloroformate

Refernces