2-(4-(8-(2-aminobenzo[d]oxazol-5-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitril

Base Information

• Chemical Name: 2-(4-(8-(2-aminobenzo[d]oxazol-5-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitril
• CAS No.: 1395145-15-9
• Molecular Formula: C₂₈H₂₂N₆O₂
• Molecular Weight: 474.522
• Mol file: 1395145-15-9.mol

Synonyms:2-(4-(8-(2-aminobenzo[d]oxazol-5-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitril

Chemical Property of 2-(4-(8-(2-aminobenzo[d]oxazol-5-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitril

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(8-(2-aminobenzo[d]oxazol-5-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitril

There total 10 articles about 2-(4-(8-(2-aminobenzo[d]oxazol-5-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-(4-(8-bromo-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile (915019-53-3) + 5-( 4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazol-2-amine (1224844-66-9) → 2-(4-(8-(2-aminobenzo[d]oxazol-5-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitril (1395145-15-9)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide; for 2h; Reflux;

Reference yield:

2-(4-aminophenyl)-2-methylpropionitrile (115279-57-7) → 2-(4-(8-(2-aminobenzo[d]oxazol-5-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitril (1395145-15-9)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid / 2 h / Reflux

2: hydrogen / Raney Ni / tetrahydrofuran; methanol / 24 h / 20 °C

4: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; ethanol; water / 2 h / Reflux

With hydrogen; sodium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; 4: Suzuki Coupling;

Reference yield:

4-(2-cyanoprop-2-yl)-1-nitrobenzene (71825-51-9) → 2-(4-(8-(2-aminobenzo[d]oxazol-5-yl)-3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitril (1395145-15-9)

Guidance literature:

Multi-step reaction with 5 steps

1: tin(ll) chloride / ethyl acetate / 2.5 h / Reflux

2: acetic acid / 2 h / Reflux

3: hydrogen / Raney Ni / tetrahydrofuran; methanol / 24 h / 20 °C

5: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; ethanol; water / 2 h / Reflux

With hydrogen; sodium carbonate; acetic acid; tin(ll) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; 5: Suzuki Coupling;

upstream raw materials:

5-Bromo-2-aminobenzoic acid

2-(4-aminophenyl)-2-methylpropionitrile

4-(2-cyanoprop-2-yl)-1-nitrobenzene

5-bromo-2-((2-nitroethenyl)amino)benzoic acid

Refernces

• 1、 -. "COMBINATION OF KINASE INHIBITORS AND USES THEREOF". . . Retrieved 2015/02/19.