1,5-difluoro-2-nitro-4-trifluoromethylbenzene

Base Information

• Chemical Name: 1,5-difluoro-2-nitro-4-trifluoromethylbenzene
• CAS No.: 35010-29-8
• Molecular Formula: C₇H₂F₅NO₂
• Molecular Weight: 227.09
• Mol file: 35010-29-8.mol

Synonyms:1,5-difluoro-2-nitro-4-trifluoromethylbenzene

Chemical Property of 1,5-difluoro-2-nitro-4-trifluoromethylbenzene

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,5-difluoro-2-nitro-4-trifluoromethylbenzene

There total 4 articles about 1,5-difluoro-2-nitro-4-trifluoromethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2,4-dichloro-5-nitrobenzotrifluoride (400-70-4) → 1,5-difluoro-2-nitro-4-trifluoromethylbenzene (35010-29-8)

Guidance literature:

With potassium fluoride; In N,N-dimethyl-formamide; at 160 - 170 ℃;

DOI:10.1021/acschemneuro.8b00726

Reference yield:

2,4-dichloro-benzotrifluoride (320-60-5) → 1,5-difluoro-2-nitro-4-trifluoromethylbenzene (35010-29-8)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium nitrate; sulfuric acid / 18.5 h / 15 - 20 °C

2: potassium fluoride / N,N-dimethyl-formamide / 160 - 170 °C

With potassium fluoride; sulfuric acid; potassium nitrate; In N,N-dimethyl-formamide;

DOI:10.1021/acschemneuro.8b00726

Reference yield:

2,4-difluoro-benzoic acid (1583-58-0) → 1,5-difluoro-2-nitro-4-trifluoromethylbenzene (35010-29-8)

Guidance literature:

Multi-step reaction with 2 steps

1: conc. H₂SO₄, HNO₃ / 0 - 5 °C

2: HF, SF₄

With sulfuric acid; sulfur tetrafluoride; hydrogen fluoride; nitric acid;

DOI:10.1021/jf9601978

upstream raw materials:

2,4-difluoro-benzoic acid

2,4-dichloro-benzotrifluoride

2,4-dichloro-5-nitrobenzotrifluoride

Refernces

• 1、 Clark, Robert D.. "Synthesis and QSAR of Herbicidal 3-Pyrazolyl α,α,α-Trifluorotolyl Ethers". . p. 3643 - 3652. Retrieved 2007/10/03.