Technology Process of methyl 6-(2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamido)hexanoate
There total 11 articles about methyl 6-(2-(3-((E)-2-(pyridin-2-yl)vinyl)-1H-indazol-6-ylthio)benzamido)hexanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
methanol; water;
at 60 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: ammonium chloride; iron / ethanol; water / 2 h / 50 °C
2.1: hydrogenchloride; sodium nitrite; acetic acid / water / 0 °C
2.2: 2 h / 0 °C
3.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; N,N-dimethyl-formamide / 80 °C
4.1: toluene-4-sulfonic acid / water; methanol / 1 h / 60 °C
With
hydrogenchloride; iron; ammonium chloride; caesium carbonate; toluene-4-sulfonic acid; acetic acid; sodium nitrite;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: thionyl chloride / N,N-dimethyl-formamide; toluene / 80 °C
2.1: potassium hydroxide / methanol / 0.17 h / 20 °C
2.2: 1 h
3.1: sodium tetrahydroborate / ethanol / 1 h
4.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane; N,N-dimethyl-formamide / 80 °C
5.1: toluene-4-sulfonic acid / water; methanol / 1 h / 60 °C
With
sodium tetrahydroborate; thionyl chloride; caesium carbonate; toluene-4-sulfonic acid; potassium hydroxide;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;