C₄₇H₆₀N₈O₆

Base Information

• Chemical Name: C₄₇H₆₀N₈O₆
• CAS No.: 1560639-00-0
• Molecular Formula: C₄₇H₆₀N₈O₆
• Molecular Weight: 833.043
• Mol file: 1560639-00-0.mol

Synonyms:C₄₇H₆₀N₈O₆

Chemical Property of C₄₇H₆₀N₈O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₇H₆₀N₈O₆

There total 20 articles about C₄₇H₆₀N₈O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C33H38N6*4ClH + N-methoxycarbonyl-L-valine (111398-44-8,74761-42-5) → C47H60N8O6 (1560639-00-0)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

N-tert-Butyloxycarbonyl-(2S,4S)-4-methylproline (364750-81-2,871727-77-4) → C47H60N8O6 (1560639-00-0)

Guidance literature:

Multi-step reaction with 8 steps

1.1: diborane / tetrahydrofuran / 2 h / 0 - 20 °C

2.1: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 2 h / 0 - 20 °C

3.1: ammonia / methanol / 1.5 h / 0 - 20 °C

3.2: 24 h / 0 - 20 °C

4.1: N-iodo-succinimide / dichloromethane / 2 h / 0 °C

5.1: water; sodium sulfite / ethanol / 30 h / 90 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 4 h / 90 °C / Inert atmosphere

7.1: hydrogenchloride / ethyl acetate / 18 h / 20 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 3 h / 0 - 20 °C

With hydrogenchloride; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-hydroxy-7-aza-benzotriazole; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; ammonia; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; diborane; sodium sulfite; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; ethyl acetate;

Reference yield:

(2S,4S)-tert-butyl 2-(hydroxymethyl)-4-methylpyrrolidine-1-carboxylate (540501-56-2) → C47H60N8O6 (1560639-00-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 2 h / 0 - 20 °C

2.1: ammonia / methanol / 1.5 h / 0 - 20 °C

2.2: 24 h / 0 - 20 °C

3.1: N-iodo-succinimide / dichloromethane / 2 h / 0 °C

4.1: water; sodium sulfite / ethanol / 30 h / 90 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 4 h / 90 °C / Inert atmosphere

6.1: hydrogenchloride / ethyl acetate / 18 h / 20 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; 1-hydroxy-7-aza-benzotriazole / dichloromethane / 3 h / 0 - 20 °C

With hydrogenchloride; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-hydroxy-7-aza-benzotriazole; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; ammonia; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium sulfite; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; ethyl acetate;

upstream raw materials:

N-methoxycarbonyl-L-valine

N-tert-Butyloxycarbonyl-(2S,4S)-4-methylproline

(2-(2-(4-bromophenyl)-2-oxoethyl)) 1-(tert-butyl) (2S,4S)-4-methylpyrrolidine-1,2-dicarboxylate

C₁₉H₂₄BrN₃O₂

Refernces

• 1、 -. "BRIDGED RING COMPOUNDS AS HEPATITIS C VIRUS (HCV) INHIBITORS AND PHARMACEUTICAL APPLICATIONS THEREOF". Paragraph 00503. . Retrieved 2014/02/16.