dibenzyl 5α-androstan-3β-yl phosphate

Base Information

• Chemical Name: dibenzyl 5α-androstan-3β-yl phosphate
• CAS No.: 230630-63-4
• Molecular Formula: C₃₃H₄₅O₄P
• Molecular Weight: 536.692
• Mol file: 230630-63-4.mol

Synonyms:dibenzyl 5α-androstan-3β-yl phosphate

Chemical Property of dibenzyl 5α-androstan-3β-yl phosphate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dibenzyl 5α-androstan-3β-yl phosphate

There total 1 articles about dibenzyl 5α-androstan-3β-yl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

5α-androstan-3β-ol (1224-93-7,7657-50-3,7753-89-1,10085-14-0,15360-52-8,15360-53-9,36216-01-0,36216-02-1,1224-92-6) + dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate (990-91-0) → dibenzyl 5α-androstan-3β-yl phosphate (230630-63-4)

Guidance literature:

With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 25h;

DOI:10.1016/S0040-4020(99)00193-3

Reference yield: 96.0%

dibenzyl 5α-androstan-3β-yl phosphate (230630-63-4) → benzyl hydrogen 5α-androstan-3β-yl phosphate (230630-64-5)

Guidance literature:

With sodium iodide; In acetone; for 18h; Heating;

DOI:10.1016/S0040-4020(99)00193-3

Reference yield:

dibenzyl 5α-androstan-3β-yl phosphate (230630-63-4) → P1,P2-bis(benzyl 5α-androstan-3β-yl) pyrophosphate (230630-67-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / sodium iodide / acetone / 18 h / Heating

2: dicyclohexyl carbodiimide / benzene / 24 h / 20 °C

With dicyclohexyl-carbodiimide; sodium iodide; In acetone; benzene; 1: debenzylation / 2: Dehydration;

DOI:10.1016/S0040-4020(99)00193-3

upstream raw materials:

5α-androstan-3β-ol

dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate

Downstream raw materials:

benzyl hydrogen 5α-androstan-3β-yl phosphate

P¹,P²-bis(benzyl 5α-androstan-3β-yl) pyrophosphate

Refernces