C₂₄H₂₄F₅N₅O₄S

Base Information

• Chemical Name: C₂₄H₂₄F₅N₅O₄S
• CAS No.: 1388149-45-8
• Molecular Formula: C₂₄H₂₄F₅N₅O₄S
• Molecular Weight: 573.544
• Mol file: 1388149-45-8.mol

Synonyms:C₂₄H₂₄F₅N₅O₄S

Chemical Property of C₂₄H₂₄F₅N₅O₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₄F₅N₅O₄S

There total 24 articles about C₂₄H₂₄F₅N₅O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(fluoromethyl)pyrazine-2-carboxylic acid (1262803-66-6) + tert-butyl ((4aS,5S,7aS)-7a-(5-amino-2-fluoro-phenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate (1388149-20-9) → C24H24F5N5O4S (1388149-45-8)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

(S)-1-(2-fluorophenyl)-2-((1,1,1-trifluorobut-3-en-2-yl)oxy)ethanone oxime (1262799-40-5) → C24H24F5N5O4S (1388149-45-8)

Guidance literature:

Multi-step reaction with 9 steps

1.1: hydroquinone / xylene / 22 h / Reflux

2.1: zinc; acetic acid / 0 - 20 °C

3.1: dichloromethane / 18 h / 20 °C

4.1: trifluoromethylsulfonic anhydride; pyridine / -20 - 0 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; methanol / 16 h / Reflux

6.1: nitric acid; trifluoroacetic acid; sulfuric acid / 1.83 h / 0 °C

6.2: pH 12 / Cooling with ice

7.1: tetrahydrofuran / 60 °C

8.1: ethanol; tin(II) chloride dihdyrate / 18 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 1 h / 20 °C

With pyridine; methanol; tin(II) chloride dihdyrate; ethanol; trifluoromethylsulfonic anhydride; sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; nitric acid; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; hydroquinone; trifluoroacetic acid; zinc; In tetrahydrofuran; dichloromethane; xylene;

Reference yield:

(S)-1-(2-fluorophenyl)-2-((1,1,1-trifluorobut-3-en-2-yl)oxy)ethanone (1262799-39-2) → C24H24F5N5O4S (1388149-45-8)

Guidance literature:

Multi-step reaction with 10 steps

1.1: hydroxylamine hydrochloride; sodium acetate / methanol / 1.5 h / 50 °C

2.1: hydroquinone / xylene / 22 h / Reflux

3.1: zinc; acetic acid / 0 - 20 °C

4.1: dichloromethane / 18 h / 20 °C

5.1: trifluoromethylsulfonic anhydride; pyridine / -20 - 0 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; methanol / 16 h / Reflux

7.1: nitric acid; trifluoroacetic acid; sulfuric acid / 1.83 h / 0 °C

7.2: pH 12 / Cooling with ice

8.1: tetrahydrofuran / 60 °C

9.1: ethanol; tin(II) chloride dihdyrate / 18 h / 20 °C

10.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 1 h / 20 °C

With pyridine; methanol; tin(II) chloride dihdyrate; ethanol; trifluoromethylsulfonic anhydride; sulfuric acid; hydroxylamine hydrochloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; nitric acid; sodium acetate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; hydroquinone; trifluoroacetic acid; zinc; In tetrahydrofuran; methanol; dichloromethane; xylene;

upstream raw materials:

5-formylpyrazine-2-carboxylic acid methyl ester

methyl 5-(hydroxymethyl)pyrazine-2-carboxylate

methyl 5-(fluoromethyl)pyrazine-2-carboxylate

5-(fluoromethyl)pyrazine-2-carboxylic acid

Downstream raw materials:

N-(3-((4aS,5S,7aS)-2-amino-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-(fluoromethyl)-pyrazine-2-carboxamide

Refernces

• 1、 -. "FUSED AMINODIHYDROTHIAZINE DERIVATIVES". . . Retrieved 2012/07/31.