1-phenylethanol-2-13C

Base Information

• Chemical Name: 1-phenylethanol-2-13C
• CAS No.: 91230-88-5
• Molecular Formula: C₈H₁₀O
• Molecular Weight: 123.156
• Mol file: 91230-88-5.mol

Synonyms:1-phenylethanol-2-13C

Chemical Property of 1-phenylethanol-2-13C

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenylethanol-2-13C

There total 1 articles about 1-phenylethanol-2-13C which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

[13C]methyl iodide (4227-95-6) + benzaldehyde (100-52-7) → 1-phenylethanol-2-13C (91230-88-5)

Guidance literature:

[13C]methyl iodide; With magnesium; In diethyl ether; for 1h; Heating;

benzaldehyde; In diethyl ether; at -5 - 25 ℃; Further stages.;

DOI:10.1021/jo070537w

Reference yield: 65.0%

1-phenylethanol-2-13C (91230-88-5) → acetophenone-β-13C (71777-36-1)

Guidance literature:

With periodic acid; pyridinium chlorochromate; In acetonitrile; for 2h;

DOI:10.1021/jo070537w

Reference yield:

1-phenylethanol-2-13C (91230-88-5) → (1S,2S,3R)-2-phenylcyclopropanemethanol-3-13C-1,2,3-2H3 (91230-94-3)

Guidance literature:

Multi-step reaction with 10 steps

1: PCC / CH₂Cl₂

2: PCl₅ / benzene / 5 h / 0 °C

3: NaNH₂ / liquid ammonia; diethyl ether / 3 h / -78 °C

4: 87 percent / D₂O, benzylhexadecyldimethylammonium chloride, NaOD / CH₂Cl₂

5: 2.) n-butyllithium / 1.) irradiation 20 min; 2.) n-butyllithium, hexane, THF, -78 deg C, 4 h 15 min

6: chiral copper catalyst / ethanol; cyclohexane / 70 °C

7: 82 percent / NaOH 25percent / methanol

9: 25percent NaOH / methanol

10: LiAlH₄ / tetrahydrofuran

With sodium hydroxide; lithium aluminium tetrahydride; n-butyllithium; deuteriated sodium hydroxide; phosphorus pentachloride; water-d2; cetyldimethylbenzylammonium chloride; sodium amide; pyridinium chlorochromate; chiral copper catalyst; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; cyclohexane; ammonia; benzene;

DOI:10.1021/ja00330a046

upstream raw materials:

[13C]methyl iodide

benzaldehyde

Downstream raw materials:

acetophenone-β-¹³C

ethylbenzene 8-13C

C₁₃⁽¹³⁾CH₁₈

C₂₄⁽¹³⁾CH₃₃N

Refernces

• 1、 Kuninobu, Yoichiro,Ueda, Hirokazu,Kawata, Atsushi,Takai, Kazuhiko. "Rearrangement of indene skeletons under mild conditions". . p. 6749 - 6752. Retrieved 2008/02/11.