N,N'-Bis<2-(4-trifluoroacetamidophenyl)benzimidazol-5-yl>terephthaloyl diamide

Base Information

• Chemical Name: N,N'-Bis<2-(4-trifluoroacetamidophenyl)benzimidazol-5-yl>terephthaloyl diamide
• CAS No.: 87353-68-2
• Molecular Formula: C₃₈H₂₄F₆N₈O₄
• Molecular Weight: 770.65
• Mol file: 87353-68-2.mol

Synonyms:N,N'-Bis<2-(4-trifluoroacetamidophenyl)benzimidazol-5-yl>terephthaloyl diamide

Chemical Property of N,N'-Bis<2-(4-trifluoroacetamidophenyl)benzimidazol-5-yl>terephthaloyl diamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-Bis<2-(4-trifluoroacetamidophenyl)benzimidazol-5-yl>terephthaloyl diamide

There total 7 articles about N,N'-Bis<2-(4-trifluoroacetamidophenyl)benzimidazol-5-yl>terephthaloyl diamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-[4-(6-Amino-1H-benzoimidazol-2-yl)-phenyl]-2,2,2-trifluoro-acetamide (345934-83-0) + terephthaloyl chloride (100-20-9) → N,N'-Bis<2-(4-trifluoroacetamidophenyl)benzimidazol-5-yl>terephthaloyl diamide (87353-68-2)

Guidance literature:

With triethylamine; In N,N-dimethyl acetamide;

DOI:10.1007/BF00506110

Reference yield:

4-(1H-benzimidazol-2-yl)aniline (2963-77-1) → N,N'-Bis<2-(4-trifluoroacetamidophenyl)benzimidazol-5-yl>terephthaloyl diamide (87353-68-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 31 percent / HNO₃, H₂SO₄ / 1 h / 0 °C

2: 65 percent / N,N-dimethyl-acetamide / 0.5 h / 0 - 5 °C

3: H₂ / Pd/C / dimethylacetamide contg. 3percent LiCl, ethanol

4: 85 percent / Et₃N / N,N-dimethyl-acetamide

With sulfuric acid; hydrogen; nitric acid; triethylamine; palladium on activated charcoal; In N,N-dimethyl acetamide;

DOI:10.1007/BF00506110

Reference yield:

5-Nitro-4'-trifluoroacetamido-2-phenylbenzimidazole (87345-59-3) → N,N'-Bis<2-(4-trifluoroacetamidophenyl)benzimidazol-5-yl>terephthaloyl diamide (87353-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / dimethylacetamide contg. 3percent LiCl, ethanol

2: 85 percent / Et₃N / N,N-dimethyl-acetamide

With hydrogen; triethylamine; palladium on activated charcoal; In N,N-dimethyl acetamide;

DOI:10.1007/BF00506110

upstream raw materials:

N-[4-(6-Amino-1H-benzoimidazol-2-yl)-phenyl]-2,2,2-trifluoro-acetamide

terephthaloyl chloride

4-(1H-benzimidazol-2-yl)aniline

5-Nitro-4'-trifluoroacetamido-2-phenylbenzimidazole

Downstream raw materials:

N,N'-Bis<2-(4-aminophenyl)benzimidazol-5-yl>terephthaloyl diamide

Refernces