NORDAMNACANTAL

Base Information

• Chemical Name: NORDAMNACANTAL
• CAS No.: 3736-59-2
• Molecular Formula: C₁₅H₈O₅
• Molecular Weight: 268.226
• Hs Code.: 2914400090
• Mol file: 3736-59-2.mol

Synonyms:2-Anthraldehyde,9,10-dihydro-1,3-dihydroxy-9,10-dioxo- (7CI,8CI); 2-Anthraquinonecarboxaldehyde,1,3-dihydroxy- (6CI); Nordamnacanthal

Chemical Property of NORDAMNACANTAL

Chemical Property:

• Vapor Pressure: 1.42E-08mmHg at 25°C
• Melting Point: 218 °C
• Boiling Point: 446.1°Cat760mmHg
• PKA: 5.08±0.20(Predicted)
• Flash Point: 237.8°C
• PSA: 91.67000
• Density: 1.6g/cm³
• LogP: 1.68570

Purity/Quality:

1,3-DIHYDROXYANTHRAQUINONE-2-CARBOXALDEHYDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of NORDAMNACANTAL

There total 8 articles about NORDAMNACANTAL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1,3-dimethoxy-2-formylanthraquinone (4480-87-9) → nordamnacanthal (3736-59-2)

Guidance literature:

1,3-dimethoxy-2-formylanthraquinone; With pyridine; aluminum (III) chloride; In dichloromethane; for 24h; Reflux;

With hydrogenchloride; In dichloromethane; water;

DOI:10.1007/s00044-012-0197-5

Reference yield:

rubiadin-1-methyl ether (7460-43-7) → nordamnacanthal (3736-59-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / tetrachloromethane / 30 h / Reflux

2.1: acetic acid; water / 24 h / Reflux

3.1: pyridinium chlorochromate / dichloromethane / 20 - 25 °C

4.1: aluminum (III) chloride / dichloromethane / 20 °C / Reflux

4.2: Cooling with ice

With aluminum (III) chloride; N-Bromosuccinimide; water; acetic acid; pyridinium chlorochromate; In tetrachloromethane; dichloromethane;

DOI:10.3390/molecules180810042

Reference yield:

2-(bromomethyl)-1,3-dimethoxyanthraquinone (63965-62-8) → nordamnacanthal (3736-59-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid; water / 24 h / Reflux

2.1: pyridinium chlorochromate / dichloromethane / 20 - 25 °C

3.1: aluminum (III) chloride / dichloromethane / 20 °C / Reflux

3.2: Cooling with ice

With aluminum (III) chloride; water; acetic acid; pyridinium chlorochromate; In dichloromethane;

DOI:10.3390/molecules180810042

upstream raw materials:

1,3-dihydroxy-2-hydroxymethyl-9,10-anthraquinone

damnacanthal

xanthopurpurin

1,3-dimethoxy-2-ethoxymethylanthraquinone

Refernces

• 1、 Akhtar, Muhammad Nadeem,Zareen, Seema,Yeap, Swee Keong,Ho, Wan Yong,Lo, Kong Mun,Hasan, Aurangzeb,Alitheen, Noorjahan Banu. "Total synthesis, cytotoxic effects of damnacanthal, nordamnacanthal and related anthraquinone analogues". . p. 10042 - 10055. Retrieved 2013/09/23.