3-fluorobenzyl formate

Base Information

• Chemical Name: 3-fluorobenzyl formate
• CAS No.: 1314664-49-7
• Molecular Formula: C₈H₇FO₂
• Molecular Weight: 154.141
• Mol file: 1314664-49-7.mol

Synonyms:3-fluorobenzyl formate

Chemical Property of 3-fluorobenzyl formate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-fluorobenzyl formate

There total 3 articles about 3-fluorobenzyl formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-fluoro-benzenemethanol (456-47-3) + formic acid ethyl ester (109-94-4) → 3-fluorobenzyl formate (1314664-49-7)

Guidance literature:

With tribromomelamine; In neat (no solvent); at 20 ℃; for 0.8h; chemoselective reaction; Green chemistry;

DOI:10.1016/S1872-2067(12)60748-7

Reference yield: 78.0%

carbon dioxide (124-38-9,18923-20-1) + 1-(Bromomethyl)-3-fluorobenzene (456-41-7) → 3-fluorobenzyl formate (1314664-49-7)

Guidance literature:

With manganese; tetra-(n-butyl)ammonium iodide; cesium fluoride; In N,N-dimethyl-formamide; for 8h; UV-irradiation;

DOI:10.1021/acscatal.9b02553

Reference yield: 64.0%

carbon dioxide (124-38-9,18923-20-1) + m-fluorobenzyl chloride (456-42-8) → 3-fluorobenzyl formate (1314664-49-7)

Guidance literature:

With manganese; tetra-(n-butyl)ammonium iodide; cesium fluoride; In N,N-dimethyl-formamide; for 8h; UV-irradiation;

DOI:10.1021/acscatal.9b02553

upstream raw materials:

3-fluoro-benzenemethanol

formic acid ethyl ester

carbon dioxide

m-fluorobenzyl chloride

Refernces

• 1、 Hajjami, Maryam,Ghorbani-Choghamarani, Arash,Karamshahi, Zahra,Norouzi, Masoomeh. "Tribromo melamine as novel and versatile catalyst for the formylation and acetylation of alcohols". . p. 260 - 263. Retrieved 2014/03/21.
• 2、 Ghorbani-Choghamarani, Arash,Goudarziafshar, Hamid,Zamani, Parisa. "Polyvinylpolypyrrolidoniume tribromide as new and metal-free catalyst for the formylation and trimethylsilylation of hydroxyl group". scheme or table. p. 1207 - 1210. Retrieved 2012/01/05.