N-Methyl-4-tert-butylbenzylaMine Hydrochloride

Base Information

• Chemical Name: N-Methyl-4-tert-butylbenzylaMine Hydrochloride
• CAS No.: 101846-35-9
• Molecular Formula: C₁₂H₁₉N*ClH
• Molecular Weight: 213.75
• Mol file: 101846-35-9.mol

Synonyms:N-4-(1,1-Dimethylethyl)-N-methyl-benzolmethanamin hydrochlorid

Chemical Property of N-Methyl-4-tert-butylbenzylaMine Hydrochloride

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

N-Methyl-4-tert-butylbenzylamine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N-Methyl-4-tert-butylbenzylamine Hydrochloride, can be used as an intermediate for the synthesis of Butenafine and it’s derivatives, acting as an antifungal.

Technology Process of N-Methyl-4-tert-butylbenzylaMine Hydrochloride

There total 1 articles about N-Methyl-4-tert-butylbenzylaMine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-methyl-4-tert-butylbenzoic acid amide (60028-84-4) → N-4-(1,1-Dimethylethyl)-N-methyl-benzolmethanamin hydrochlorid (101846-35-9)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; for 1h; Ambient temperature;

DOI:10.1002/ardp.19933260607

Reference yield: 46.0%

sodium cyanide (143-33-9,25596-52-5) + 1-naphthaldehyde (66-77-3) + N-4-(1,1-Dimethylethyl)-N-methyl-benzolmethanamin hydrochlorid (101846-35-9) → (α-<4-(1,1-Dimethylethyl)phenylmethyl>-N-methyl>-amino)-1-naphthalinacetonitril

Guidance literature:

In methanol; for 6h; Heating;

DOI:10.1002/ardp.19933260607

Reference yield:

N-4-(1,1-Dimethylethyl)-N-methyl-benzolmethanamin hydrochlorid (101846-35-9) → 2,3-Dihydro-N-<4-(1,1-dimethylethyl)phenylmethyl>-N,2-dimethyl-7-benzofuranmethanamin-Hydrochlorid

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / toluene / 1 h / Ambient temperature

2: 72 percent / Red-Al^R / toluene / 1 h / Ambient temperature

With triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene;

DOI:10.1002/ardp.19933260608

upstream raw materials:

N-methyl-4-tert-butylbenzoic acid amide

Downstream raw materials:

2,3-Dihydro-N-<4-(1,1-dimethylethyl)phenylmethyl>-N,2-dimethyl-7-benzofurancarboxamid

N-<4-(1,1-Dimethylethyl)phenylmethyl>-N,2-dimethyl-3-nitro-benzoesaeurecarboxamid

N-<4-(1,1-Dimethylethyl)phenylmethyl>-N,3-dimethyl-2-nitro-benzoesaeurecarboxamid

2,3-Dihydro-N-<4-(1,1-dimethylethyl)phenylmethyl>-N-methyl-7-benzofurancarboxamid

Refernces