(2R)-3-cyclohexyl-2-hydroxypropionic acid

Base Information

• Chemical Name: (2R)-3-cyclohexyl-2-hydroxypropionic acid
• CAS No.: 156469-00-0
• Molecular Formula: C₉H₁₆O₃
• Molecular Weight: 172.224
• Mol file: 156469-00-0.mol

Synonyms:(2R)-3-cyclohexyl-2-hydroxypropionic acid

Chemical Property of (2R)-3-cyclohexyl-2-hydroxypropionic acid

Chemical Property:

Purity/Quality:

99.9% ^*data from raw suppliers

(R)-a-Hydroxy-cyclohexanepropanoicacid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-3-cyclohexyl-2-hydroxypropionic acid

There total 16 articles about (2R)-3-cyclohexyl-2-hydroxypropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

D-phenyllactic acid (828-01-3,7326-19-4,20312-36-1,156-05-8) → (2R)-3-cyclohexyl-2-hydroxypropionic acid (156469-00-0)

Guidance literature:

With hydrogen; Rh/Al₂O₃; for 48h; under 2250.23 Torr;

Reference yield: 98.0%

(R)-methyl 2-hydroxy-3-cyclohexylpropanoate (128659-92-7) → (2R)-3-cyclohexyl-2-hydroxypropionic acid (156469-00-0)

Guidance literature:

(R)-methyl 2-hydroxy-3-cyclohexylpropanoate; With lithium hydroxide monohydrate; In methanol; water; at 25 ℃;

In methanol; water;

DOI:10.1021/op030202q

Reference yield:

3-cyclohexyl-D-alanine (58717-02-5) → (2R)-3-cyclohexyl-2-hydroxypropionic acid (156469-00-0)

Guidance literature:

With sulfuric acid; sodium nitrite; In water; at 0 - 20 ℃;

DOI:10.1021/jo050156n

upstream raw materials:

D-phenyllactic acid

3-cyclohexyl-D-alanine

(S)-3-cyclohexyl-2-hydroxypropionic acid

L-cyclohexylalanine

Downstream raw materials:

(2R)-2-hydroxy-3-cyclohexyl-propionic acid benzyl ester

(S)-5-(tert-Butyl-dimethyl-silanyloxy)-4-((R)-3-cyclohexyl-2-hydroxy-propionylamino)-pentanoic acid trityl-amide

2-{2-[2-benzyloxymethyl-3-(3,4,5-tris-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-tetrahydro-pyran-4-yloxy]-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-4-yloxy}-3-cyclohexyl-propionic acid benzyl ester

(R)-methyl 2-hydroxy-3-cyclohexylpropanoate

Refernces

• 1、 -. "GLYCOMIMETIC ANTAGONISTS FOR BOTH E- AND P-SELECTINGS". Figure 7A. . Retrieved 2010/02/12.
• 2、 Glueck, Silvia M.,Larissegger-Schnell, Barbara,Csar, Katrin,Kroutil, Wolfgang,Faber, Kurt. "Biocatalytic racemisation of α-hydroxycarboxylic acids at physiological conditions". . p. 1904 - 1905. Retrieved 2007/10/03.