Methyl hydrazinecarbodithioate

Base Information

• Chemical Name: Methyl hydrazinecarbodithioate
• CAS No.: 5397-03-5
• Molecular Formula: C2H6N2S2
• Molecular Weight: 122.215
• Hs Code.: 2930909090
• European Community (EC) Number: 812-150-1
• NSC Number: 4423
• UNII: R2L2YRR7MP
• DSSTox Substance ID: DTXSID3063835
• Nikkaji Number: J108.712F
• Mol file: 5397-03-5.mol

Synonyms:methyldithiocarbazate

Chemical Property of Methyl hydrazinecarbodithioate

Chemical Property:

• Vapor Pressure: 0.227mmHg at 25°C
• Melting Point: 79 °C(Solv: benzene (71-43-2))
• Refractive Index: 1.645
• Boiling Point: 207.3 °C at 760 mmHg
• PKA: 9.15±0.70(Predicted)
• Flash Point: 79.2 °C
• PSA: 95.44000
• Density: 1.314 g/cm³
• LogP: 1.18880
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 121.99724055
• Heavy Atom Count: 6
• Complexity: 53.5

Purity/Quality:

98%, ^*data from raw suppliers

Methyl hydrazinecarbodithioate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CSC(=S)NN

Technology Process of Methyl hydrazinecarbodithioate

There total 14 articles about Methyl hydrazinecarbodithioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

(S,S)-dimethyl trithiocarbonate (2314-48-9) → hydrazinecarbodithioic acid methyl ester (5397-03-5)

Guidance literature:

With hydrazine hydrate; In ethanol; at 0 ℃; for 3h;

DOI:10.1246/bcsj.69.1043

Reference yield: 90.0%

carbon disulfide (75-15-0,12122-00-8) + methyl iodide (74-88-4) → hydrazinecarbodithioic acid methyl ester (5397-03-5)

Guidance literature:

carbon disulfide; With hydrazine hydrate; potassium hydroxide; In water; isopropyl alcohol; at 0 - 10 ℃; for 3h;

methyl iodide; In water; isopropyl alcohol; at 20 ℃; for 4h; Cooling with ice;

Reference yield: 90.0%

carbon disulfide (75-15-0,12122-00-8) + hydrazine (302-01-2,78206-91-4,119775-10-9,75013-58-0) + methyl iodide (74-88-4) → hydrazinecarbodithioic acid methyl ester (5397-03-5)

Guidance literature:

With potassium hydroxide; In water; isopropyl alcohol; at 20 ℃; for 4h;

DOI:10.1016/j.bmcl.2013.08.028

upstream raw materials:

S-ammonium hydrazinecarbodithiolate

dimethyl sulfate

carbon disulfide

methyl iodide

Downstream raw materials:

5-methylsulfanyl-3H-[1,3,4]thiadiazol-2-one

methyl 2-(4-methoxybenzylidene)hydrazinecarbodithioate

methyl 2-(2-hydroxybenzylidene)hydrazinecarbodithioate

(5-methylsulfanyl-[1,3,4]thiadiazol-2-yl)-phenyl-amine

Refernces

• 1、 Biot, Christophe,Pradines, Bruno,Sergeant, Marie-Helene,Gut, Jiri,Rosenthal, Philip J.,Chibale, Kelly. "Design, synthesis, and antimalarial activity of structural chimeras of thiosemicarbazone and ferroquine analogues". . p. 6434 - 6438. Retrieved 2007.
• 2、 Kubaisi,Ismail. "Nickel(II) and palladium(II) chelates of dehydroacetic acid Schiff bases derived from thiosemicarbazide and hydrazinecarbodithioate". . p. 1785 - 1788. Retrieved 1994.
• 3、 Wang, Tingting,Miao, Wenke,Wu, Shanshan,Bing, Guifang,Zhang, Xin,Qin, Zhenfang,Yu, Haibo,Qin, Xue,Fang, Jianxin. "Synthesis, crystal structure, and herbicidal activities of 2-cyanoacrylates containing 1,3,4-thiadiazole moieties". . p. 959 - 967. Retrieved 2011.
• 4、 -. "Synthetic method 2 -methylsulfonyl -5 - trifluoromethyl -1 , 3, 4 - thiadiazole". Paragraph 0011. . Retrieved 2021/10/20.
• 5、 Franz, Katherine J.,Hunsaker, Elizabeth W.,McAuliffe, Katherine J.. "Fluconazole analogues with metal-binding motifs impact metal-dependent processes and demonstrate antifungal activity in Candida albicans". . . Retrieved 2020/06/26.