8-(2-Nitro-phenylselanyl)-octanoic acid methyl ester

Base Information

• Chemical Name: 8-(2-Nitro-phenylselanyl)-octanoic acid methyl ester
• CAS No.: 108545-35-3
• Molecular Formula: C₁₅H₂₁NO₄Se
• Molecular Weight: 358.296
• Mol file: 108545-35-3.mol

Synonyms:8-(2-Nitro-phenylselanyl)-octanoic acid methyl ester

Chemical Property of 8-(2-Nitro-phenylselanyl)-octanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-(2-Nitro-phenylselanyl)-octanoic acid methyl ester

There total 3 articles about 8-(2-Nitro-phenylselanyl)-octanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ortho-nitrophenyl selenocyanate (51694-22-5) + methyl 8-bromooctanoate (26825-92-3) → 8-(2-Nitro-phenylselanyl)-octanoic acid methyl ester (108545-35-3)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 13h; Ambient temperature;

DOI:10.1246/bcsj.59.3535

Reference yield:

1,8-Octanediol (629-41-4) → 8-(2-Nitro-phenylselanyl)-octanoic acid methyl ester (108545-35-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) 48 percent HBr, concd. H₂SO₄; 2.) KMnO₄ / 1.) 3 h, reflux; 2.) 20percent H₂SO₄, 15-20 deg C

3: 75 percent / NaBH₄ / ethanol / 13 h / Ambient temperature

With sodium tetrahydroborate; potassium permanganate; sulfuric acid; hydrogen bromide; In ethanol;

DOI:10.1246/bcsj.59.3535

Reference yield:

8-bromooctanoic acid (17696-11-6) → 8-(2-Nitro-phenylselanyl)-octanoic acid methyl ester (108545-35-3)

Guidance literature:

Multi-step reaction with 2 steps

2: 75 percent / NaBH₄ / ethanol / 13 h / Ambient temperature

With sodium tetrahydroborate; In ethanol;

DOI:10.1246/bcsj.59.3535

upstream raw materials:

ortho-nitrophenyl selenocyanate

methyl 8-bromooctanoate

1,8-Octanediol

8-bromooctanoic acid

Downstream raw materials:

methyl hept-6-ynoate

oct-7-ynoic acid

hept-6-ynoic acid

Refernces